A Case-Control Study of Sociodemographic and Geographic Characteristics of 335 Children With Eosinophilic Esophagitis
A Case-Control Study of Sociodemographic and Geographic Characteristics of 335 Children With Eosinophilic Esophagitis
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DOI：
10.1016/j.cgh.2008.10.006
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发表时间：
2009-04-01
影响因子：
12.6
通讯作者：
Spergel, Jonathan M.
中科院分区：
文献类型：
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作者：
Franciosi, James P.;Tam, Vicky;Spergel, Jonathan M.
背景与目的：儿童嗜酸性食管炎（EE）的流行病学特征不明确。在这项研究中，我们的目的是确定我们的EE儿童队列的人口统计学，社会经济和地理特征。研究方法：采用病例对照设计，将335例EE受试者与来自胃肠病学（GI）和过敏诊所的对照受试者以及2000例美国人口普查数据进行比较。结果如下：EE受试者与大费城人群以及来自我们胃肠病学和过敏诊所的对照受试者有显著差异。EE受试者中83.6%是白人，而GI对照受试者中70.9%是白人（比值比[OR]，2.17; P <0.001;置信区间[CI]，1.52-3.11），过敏对照受试者中64.9%（OR，2.83; P <0.001; CI，1.99-4.04），以及大费城人口的73.0%。EE受试者中男性占75.8%，而GI对照受试者中男性占48.0%（OR，3.39; P <0.001; CI，2.47-4.65），过敏对照受试者中男性占60.4%（OR，1.62; P <0.001; CI，1.19-2.19），大费城人群中男性占48.0%。我们最初表明，EE科目更富裕，教育程度更高，更经常居住在郊区。然而，高加索人种是一个重要的混杂变量，并解释了EE受试者和我们的对照人群之间的社会经济或地理差异，只有一个例外。在EE和过敏控制人群中，郊区和城市居民之间存在显着差异。结论：EE受试者在白人种族和男性性别的人口统计学特征方面与对照组有显著差异。当调整种族作为混杂因素时，EE受试者的社会经济和地理特征与我们的典型GI诊所转诊模式没有差异。
Background & Aims: The epidemiology of pediatric eosinophilic esophagitis (EE) is poorly characterized. In this study, we aimed to determine demographic, socioeconomic, and geographic characteristics of our cohort of EE children. Methods: A case-control design was used to compare 335 EE subjects with control subjects from gastroenterology (GI) and allergy clinics as well as 2000 U.S. census data. Results: EE subjects were significantly different than the greater Philadelphia population as well as control subjects from our gastroenterology and allergy clinics. EE subjects were 83.6% Caucasian, compared with 70.9% of GI control subjects (odds ratio [OR], 2.17; P < .001; confidence interval [CI], 1.52-3.11), 64.9% of allergy control subjects (OR, 2.83; P < .001; CI, 1.99-4.04), and 73.0% of the greater Philadelphia population. EE subjects were 75.8% male, compared with 48.0% of GI control subjects (OR, 3.39; P < .001; CI, 2.47-4.65), 60.4% of allergy control subjects (OR, 1.62; P < .001; CI, 1.19-2.19), and 48.0% of the greater Philadelphia population. We initially demonstrated that EE subjects are more affluent, more educated, and reside more often in suburban areas. However, Caucasian race was a significant confounding variable and accounted for socioeconomic or geographic differences among EE subjects and our control populations with one exception. A significant difference remained between suburban and urban residence in EE and allergy control populations. Conclusions: EE subjects are significantly different than control groups in their demographic characteristics of Caucasian race and male sex. EE subject socioeconomic and geographic characteristics a-re not different than our typical referral patterns to GI clinic when adjusted for race as a confounding factor.