A computational model of a human single sinoatrial node cell
A computational model of a human single sinoatrial node cell
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DOI：
10.1088/2057-1976/2/3/035006
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发表时间：
2016-06-01
影响因子：
1.4
通讯作者：
Leonhardt, S.
中科院分区：
文献类型：
--
作者：
Pohl, A.;Wachter, A.;Leonhardt, S.
为了研究心脏神经调节作用下的自发性节律活动反应，我们建立了人窦房结（SAN）细胞模型。为了降低心率升高，我们希望建立一个硬件在环系统，包括该模型，以分析神经刺激系统的最佳刺激模式。基本模型结构采用文献中可用的兔SAN细胞模型，并用霍奇金-赫胥黎模型方程来描述单个离子通道复杂的随时间和电压变化的激活和失活过程。由此产生的模型由15个电流组成，这些电流目前已知负责膜动作电位（AP）的产生。该模型再现的AP频率相当于在分离的人类SAN细胞中测量到的频率，结果hrf为71.8 bpm。通过模拟伊伐布雷定的抑制作用对模型进行验证，结果与人体研究的实验结果一致。此外，我们可以在人体试验研究中验证该模型对副交感神经刺激的影响。
For the investigation of the spontaneous rhythmical activity response in the application of cardiac neuromodulation, we formulated a human sinoatrial node (SAN) cell model. With the aim of decreasing elevated heart rate (HR), we want to establish a hardware-in-the-loop system including this model for the analysis of optimal stimulation patterns of the neurostimulation system. Base model structures are adopted from rabbit SAN cell models available in literature and conveyed with Hodgkin-Huxley-type model equations describing the complex time and voltage dependent activation and deactivation processes of individual ion channels. The resulting model consists of 15 currents which are currently known to be responsible for the generation of the membrane action potential (AP). The model reproduces AP frequencies equivalent to those measured in isolated human SAN cells with a resultingHRof 71.8 bpm. Model validation via simulation of the inhibitory effect of ivabradine showed accordance with experimental results obtained in human studies. Furthermore, we could validate the model in regard to itsHReffects upon parasympathetic stimulation with results obtained in a human trial study.