Elastic properties of air- and liquid-filled lung parenchyma.
Elastic properties of air- and liquid-filled lung parenchyma.
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充满空气和液体的肺实质的弹性特性。
DOI：
10.1152/jappl.1988.65.6.2565
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Yager,D
中科院分区：
文献类型：
--
作者：
Stamenovic,D;Yager,D
压力-体积测量和冲压压痕试验用于获得填充空气和液体的兔肺的肺实质的体积模量（kappa）和剪切模量（mu）。从这些测量中获得的kappa和mu与经肺压的曲线图表明，充满空气和液体的肺的弹性行为之间的差异很小，这表明两种情况下抵抗变形的机制是相似的。另一方面，从kappa和mu对肺体积的曲线图来看，在相同体积下，充气肺中的弹性模量似乎高于充液肺中的弹性模量。这些差异，称为kappa γ和mu γ，以及经肺动脉压（P γ）的差异，可能是由于肺泡表面张力（γ）提供的充气肺的额外弹性回缩。无法得出关于kappa伽马与P伽马曲线形状的结论。然而，μ γ与P γ的关系似乎近似线性，斜率约为0.5。这一结果与模型（T. A. Wilson和H. Bachofen，J.Appl.Physiol.52：1064-1070，1982），其中提供P γ的薄壁组织部分被描绘为在机械上类似于开孔液体泡沫，具有μ γ = 0.4P γ（J. Appl. Mech. Trans. ASME 51：229-231，1984），但其仅在高肺体积下具有统计学显著性。
Pressure-volume measurements and the punch indentation test are used to obtain the bulk modulus (kappa) and the shear modulus (mu) of lung parenchyma of air- and liquid-filled rabbit lungs. Plots of kappa and mu vs. transpulmonary pressure obtained from these measurements indicate that there is very little difference between the elastic behavior of the air- and liquid-filled lung, suggesting that the mechanism of resisting deformation in both cases is similar. On the other hand, from plots of kappa and mu vs. lung volume, it appears that the elastic moduli are higher in the air-filled lung than in the liquid-filled lung at the same volume. These differences, referred to as kappa gamma and mu gamma, as well as the difference in transpulmonary pressures (P gamma), are presumably due to the additional elastic recoil of the air-filled lung provided by alveolar surface tension (gamma). No conclusion could be reached about the shape of the kappa gamma vs. P gamma curve. However, the mu gamma vs. P gamma relationship appears to be approximately linear, with a slope of approximately 0.5. This result agrees qualitatively with the model (T. A. Wilson and H. Bachofen, J. Appl. Physiol. 52: 1064-1070, 1982) in which the part of the parenchyma that provides P gamma is pictured as mechanically analogous to an open cell liquid foam, having mu gamma = 0.4P gamma (J. Appl. Mech. Trans. ASME 51: 229-231, 1984), but it is statistically significant only at high lung volumes.