Premature Birth and Age at Onset of Puberty
Premature Birth and Age at Onset of Puberty
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DOI：
10.1097/ede.0b013e31824d5fd0
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发表时间：
2012-05-01
期刊：
影响因子：
5.4
通讯作者：
Schooling, C. Mary
中科院分区：
文献类型：
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作者：
Hui, Lai Ling;Leung, Gabriel M.;Schooling, C. Mary
背景资料：早产是与不良的代谢健康在两个性别，可能通过早期的青春期timing.Methods：我们研究了孕龄和早产的协会（= 41周的妊娠（时间比= 1.04 [95%置信区间= 1.01-1.06]），调整母亲的初潮年龄，母亲的出生地点，并在怀孕期间吸烟。在男孩中，生育年龄与青春期的开始无关（性别交互作用检验，P < 0.01）。没有这些协会被改变调整的社会经济地位或不同的儿童身高或BMI.Conclusions：早产是不相关的青春期的早期发病，相反，早产的女孩有较晚的青春期发病。因此，早产和随后的心血管风险之间的关联可能不是通过青春期开始的时间来介导的。目前还不清楚是否青春期的开始，持续时间或克里思更相关的青春期早期的有害后果。进一步研究宫内、婴儿和儿童期对青春期持续时间和克里思的影响可能有助于揭示心血管疾病的早期起源。
Background: Premature birth is associated with poor metabolic health in both sexes, potentially via earlier pubertal timing.Methods: We examined the associations of gestational age and premature birth (= 41 weeks' gestation (time ratio = 1.04 [95% confidence interval = 1.01-1.06]), adjusted for mother' age of menarche, mother's place of birth, and smoking during pregnancy. Gestational age was not associated with onset of puberty in boys (test for interaction by sex, P < 0.01). None of these associations was altered by adjustment for socioeconomic position or varied with childhood height or BMI.Conclusions: Premature birth was not related to earlier onset of puberty; instead, premature girls had later onset of puberty. Thus, the association between premature birth and subsequent cardiovascular risk is probably not mediated through the timing of pubertal onset. It is unclear whether onset, duration, or tempo of puberty is more relevant to the detrimental consequences of early puberty. Further studies investigating intrauterine, infant, and childhood influences on the duration and tempo of puberty may help unravel the early origins of cardiovascular diseases.