Particulate matter air pollution exposure disrupts the Nrf2 pathway in sinonasal epithelium via epigenetic alterations in a murine model.
Particulate matter air pollution exposure disrupts the Nrf2 pathway in sinonasal epithelium via epigenetic alterations in a murine model.
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DOI:
10.1002/alr.23010
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发表时间:
2022-11
影响因子:
6.4
通讯作者:
Ramanathan M Jr
中科院分区:
文献类型:
--
作者:
Park B;London NR Jr;Tharakan A;Rengasamy P;Rajagopalan S;Biswal S;Pinto JM;Ramanathan M Jr
Exposure to airborne environmental pollutants including fine particulate matter (PM2. 5) has been linked to respiratory disease, including chronic rhinosinusitis (CRS), allergies, and anosmia. 1 Recent work has established a link between PM2. 5 exposure and the development of nonallergic CRS. 1 In addition, CRS symptom severity is influenced by air pollutant exposure, and chronic PM2. 5 exposure has been found to induce sinonasal epithelial barrier dysfunction and type 2 eosinophilic rhinosinusitis in
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