Gender differences in antiretroviral treatment outcomes of HIV patients in rural Uganda
Gender differences in antiretroviral treatment outcomes of HIV patients in rural Uganda
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DOI：
10.1080/09540120903193625
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发表时间：
2010-01-01
影响因子：
1.7
通讯作者：
Rubaale, Tom
中科院分区：
文献类型：
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作者：
Kipp, Walter;Alibhai, Arif;Rubaale, Tom
对乌干达西部卡巴罗莱区305名接受抗逆转录病毒治疗（ART）的艾滋病毒感染者治疗结果的性别差异进行了评价。主要治疗结果是定义为HIV-1 RNA病毒载量（VL）B400拷贝/ml的病毒学抑制，次要结果指标是ART治疗6个月后CD 4细胞计数的增加。统计分析包括描述性、单变量和多变量方法。从比例上看，选择寻求治疗的女性多于男性。治疗6个月后，与男性相比，女性更有可能获得病毒抑制（VL > 400拷贝/ml）（比值比2.14，95%置信区间0.99-4.63，p = 0.05）。虽然女性在治疗开始时的基线CD 4细胞计数显著高于男性，但接受ART治疗6个月后，男性和女性的CD 4细胞计数增加相似。应进一步调查女性ART结果更好的原因。理想情况下，如果性别差异的原因在于患者行为和ART服务的提供方式，ART项目应该努力实现男性和女性公平的治疗结果。
Gender differences in treatment outcomes of 305 persons living with HIV receiving antiretroviral treatment (ART) in Kabarole district, western Uganda, were evaluated. The primary treatment outcome was virological suppression defined as HIV-1 RNA viral load (VL) B400 copies/ml and the secondary outcome measure was the increase in the CD4 cell count after six months on ART. Statistical analysis included descriptive, univariate, and multivariate methods. Proportionally, more females chose to seek treatment compared to males. After six months of treatment, females were more likely to have viral suppression (VL > 400 copies/ml) as compared to males (odds ratio 2.14, 95% confidence interval 0.99-4.63, p = 0.05). While females had a significantly higher baseline CD4 cell count at initiation of treatment compared to males, the increase in CD4 cell count after six months on ART was similar in males and females. The reasons for better ART outcomes for females should be further investigated. Ideally, ART programs should work toward equitable treatment outcomes for men and women, if the cause of the gender differential lies in patient behavior and the way ART services are delivered.