QUANTIFICATION OF LIVER VISCOELASTICITY WITH ACOUSTIC RADIATION FORCE: A STUDY OF HEPATIC FIBROSIS IN A RAT MODEL
QUANTIFICATION OF LIVER VISCOELASTICITY WITH ACOUSTIC RADIATION FORCE: A STUDY OF HEPATIC FIBROSIS IN A RAT MODEL
复制标题
用声辐射力量化肝脏粘弹性：大鼠模型肝纤维化的研究
DOI：
10.1016/j.ultrasmedbio.2013.05.020
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发表时间：
2013-11-01
影响因子：
2.9
通讯作者：
Chen, Siping
中科院分区：
文献类型：
--
作者：
Chen, Xin;Shen, Yuanyuan;Chen, Siping
超声弹性成像，基于剪切波传播，使定量和非侵入性评估肝脏的机械性能，如刚度，并已被发现是可行的，并在肝纤维化的诊断有用。大多数超声弹性成像方法使用纯粹的弹性模型来描述肝脏的机械特性。然而，为了描述分散的组织并获得组织弹性的准确测量，应该检查组织的粘弹性。本研究的目的是调查剪切粘弹性特性，超声弹性成像测量，肝纤维化大鼠模型，并评估诊断准确性的粘弹性分期肝纤维化。用四氯化碳（CCl 4）诱导37只大鼠肝纤维化，6只大鼠作为对照。利用声辐射力诱导的剪切波测量离体肝脏的粘弹性。对于纤维化阶段F0-F4，测量的肝脏弹性和粘度的平均值分别为0.84至3.45 kPa和1.12至2.06 Pa.s。斯皮尔曼相关系数显示纤维化分期与弹性相关（0.88），与粘度相关（0.66）。弹性的受试者工作特征曲线下的面积分别为0.97（>= F2）、0.91（>= F3）和1.00（F4），粘度的受试者工作特征曲线下的面积分别为0.91（>= F2）、0.79（>= F3）和0.74（F4）。结果证实，剪切波速度是分散的频率，建议粘弹性模型来描述肝纤维化。该研究发现，虽然粘度不如纤维化分期的弹性好，但重要的是要考虑粘度以准确估计弹性;它还可以提供对肝组织的其他机械见解。（电子邮件：tfwang@szu.edu.cn或chensiping@szu.edu.cn）（C）2013年世界医学和生物学超声联合会。
Ultrasound elastography, based on shear wave propagation, enables the quantitative and non-invasive assessment of liver mechanical properties such as stiffness and has been found to be feasible for and useful in the diagnosis of hepatic fibrosis. Most ultrasound elastographic methods use a purely elastic model to describe liver mechanical properties. However, to describe tissue that is dispersive and to obtain an accurate measure of tissue elasticity, the viscoelasticity of the tissue should be examined. The objective of this study was to investigate the shear viscoelastic characteristics, as measured by ultrasound elastography, of liver fibrosis in a rat model and to evaluate the diagnostic accuracy of viscoelasticity for staging liver fibrosis. Liver fibrosis was induced in 37 rats using carbon tetrachloride (CCl4); 6 rats served as controls. Liver viscoelasticity was measured in vitro using shear waves induced by acoustic radiation force. The measured mean values of liver elasticity and viscosity ranged from 0.84 to 3.45 kPa and from 1.12 to 2.06 Pa.s for fibrosis stages F0-F4, respectively. Spearman correlation coefficients indicated that stage of fibrosis was well correlated with elasticity (0.88) and moderately correlated with viscosity (0.66). The areas under receiver operating characteristic curves were 0.97 (>= F2), 0.91 (>= F3) and 1.00 (F4) for elasticity and 0.91 (>= F2), 0.79 (>= F3) and 0.74 (F4) for viscosity, respectively. The results confirmed that shear wave velocity was dispersive in frequency, suggesting a viscoelastic model to describe liver fibrosis. The study finds that although viscosity is not as good as elasticity for staging fibrosis, it is important to consider viscosity to make an accurate estimation of elasticity; it may also provide other mechanical insights into liver tissues. (Email: tfwang@szu.edu.cn or chensiping@szu.edu.cn) (C) 2013 World Federation for Ultrasound in Medicine & Biology.