Centrally-induced vasopressor responses to carbachol are augmented in DOCA-salt hypertensive rats.
Centrally-induced vasopressor responses to carbachol are augmented in DOCA-salt hypertensive rats.
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在 DOCA 盐高血压大鼠中，中枢诱导的对卡巴胆碱的血管升压反应增强。
DOI：
10.1093/cvr/18.2.126
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发表时间：
1984
影响因子：
10.8
通讯作者：
H. Ijichi
中科院分区：
文献类型：
--
作者：
H. Takahashi;A. Inoue;K. Takeda;H. Okajima;S. Sasaki;I. Iyoda;M. Yoshimura;M. Nakagawa;H. Ijichi
在大鼠中建立的DOCA盐高血压中已经证明了交感神经系统活动和加压素释放增加。为了确定这些机制的重要性，在中枢介导的升压反应，在这个模型的高血压，清醒的大鼠和大鼠麻醉与氨基甲酸乙酯脑室内注射卡巴胆碱。在植入含有DOCA的硅橡胶模具后，随后用1%盐水的自来水替代，收缩压从112 +/- 3 mmHg增加到4周结束时的稳定188 +/- 7 mmHg，使用尾套法测量。当卡巴胆碱注射到清醒大鼠的脑室时，血压持续升高。在正常血压大鼠（NTR）、假手术大鼠（SHAM）和DOCA-盐性高血压大鼠（DOCA）三组中，DOCA大鼠的升压相幅度最大。所有三组大鼠的心率都类似地下降。当随后用氨基甲酸乙酯麻醉大鼠以记录腹部交感神经活动时，卡巴胆碱注射引起双相血压反应和交感神经放电，包括初始血管抑制和短时间的交感神经抑制。随后是一个持续的升压阶段，伴随着交感神经活动的相应增加。DOCA组的升压反应幅度再次大于SHAM组大鼠。脊髓切断可消除初始降压相，但对持续升压相影响不大。（250字处删节）
Increased sympathetic nervous system activity and vasopressin release has been demonstrated in established DOCA-salt hypertension in the rat. To determine the importance of these mechanisms in centrally-mediated pressor responses in this model of hypertension, both awake rats and rats anaesthetised with urethane were given intracerebroventricular injections of carbachol. The systolic blood pressure after implanting a silicon rubber mould containing DOCA, and with subsequent substitution of 1% saline in tap water, increased from 112 +/- 3 mmHg to a stable 188 +/- 7 mmHg by the end of 4 weeks, measured using a tail-cuff method. The blood pressure consistently became elevated when carbachol was injected into the cerebral ventricles of awake rats. Of the three groups of normotensive rats (NTR), sham-operated rats (SHAM) and DOCA-salt hypertensive rats (DOCA), the magnitude of the pressor phase was largest in the DOCA rats. The heart rate in all three groups of rats decreased similarly. When the rats were later anaesthetised with urethane to allow recording of abdominal sympathetic nerve activity, the carbachol injections caused biphasic blood pressure responses and sympathetic nerve discharge consisting of initial vasodepression and sympathetic nerve inhibition of short duration. This was followed by a sustained pressor phase accompanied by a corresponding increase in sympathetic nerve activity. The magnitude of the pressor response was again larger in the DOCA than in the SHAM rats. Spinal section abolished the initial depressor phase but did not much affect the sustained pressor phase.(ABSTRACT TRUNCATED AT 250 WORDS)