Caveolin-1, a putative tumour suppressor gene
Caveolin-1, a putative tumour suppressor gene
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DOI：
10.1042/bst0290494
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发表时间：
2001-08-01
影响因子：
3.9
通讯作者：
Lisanti, MP
中科院分区：
文献类型：
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作者：
Razani, B;Schlegel, A;Lisanti, MP
小窝（“小洞”）是直径为50-100 nm的质膜特化，小窝蛋白是细胞用于形成小窝的结构蛋白。我们和其他研究人员已经发现，细胞器的小窝可能是重要的，在正常的信号转导和一些人类疾病的发病机制，如癌症。在这里，我们描述了小窝蛋白基因家族的功能作用，并总结了支持小窝作为介质的一些细胞信号传导过程，包括细胞凋亡的作用的证据。
Caveolae ('little caves') are plasma membrane specializations of 50-100 nm in diameter, and the caveolins are structural proteins used by cells to form caveolae. We and other investigators have discovered that caveolae organelles may be important both in normal signal transduction and in the pathogenesis of a number of human diseases, such as cancer. Here we describe the functional roles of the caveolin gene family and summarize the evidence that supports a role for caveolae as mediators of a number of cellular signalling processes, including apoptosis.