Risk of COVID-19 in health-care workers in Denmark: an observational cohort study
Risk of COVID-19 in health-care workers in Denmark: an observational cohort study
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DOI：
10.1016/s1473-3099(20)30589-2
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发表时间：
2020-12-01
影响因子：
56.3
通讯作者：
Mlum, Henrik
中科院分区：
文献类型：
--
作者：
Iversen, Kasper;Bundgaard, Henning;Mlum, Henrik
背景 医护人员被认为高度暴露于严重急性呼吸综合征冠状病毒 2 (SARS-CoV-2) 感染。我们的目的是调查医护人员中 SARS-CoV-2 抗体的流行情况，以及血清转化的医护人员中曾出现过 COVI D-19 症状的比例。 方法 在这项观察性队列研究中，对丹麦首都地区的医护人员进行了筛查，包括该地区医院相关的医务人员、护理人员和其他学生。筛查包括针对 SARS-CoV-2 的 IgM 和 IgG 抗体的即时检测。记录测试结果和参与者特征。结果与研究期间首都地区献血者的结果进行了比较。结果 2020 年 4 月 15 日至 23 日期间，我们筛查了 29 295 名医护人员，其中 28 792 名（98.28%）提供了检测结果。我们确定了 1163 名（4.04% [95% CI 3.82-4.27]）血清反应呈阳性的医护人员。医护人员的血清阳性率高于献血者（4672 人中的 142 人 [3.04%]；风险比 [RR] 1.33 [95% CI 142-1.58]；p
Background Health-care workers are thought to be highly exposed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. We aimed to investigate the prevalence of antibodies against SARS-CoV-2 in health-care workers and the proportion of seroconverted health-care workers with previous symptoms of COVI D-19.Methods In this observational cohort study, screening was offered to health-care workers in the Capital Region of Denmark, including medical, nursing, and other students who were associated with hospitals in the region. Screening included point-of-care tests for IgM and IgG antibodies against SARS-CoV-2. Test results and participant characteristics were recorded. Results were compared with findings in blood donors in the Capital Region in the study period.Findings Between April 15 and April 23, 2020, we screened 29 295 health-care workers, of whom 28 792 (98.28%) provided their test results. We identified 1163 (4.04% [95% CI 3.82-4.27]) seropositive health-care workers. Seroprevalence was higher in health-care workers than in blood donors (142 [3.04%] of 4672; risk ratio [RR] 1.33 [95% CI 142-1.58]; p