Pluripotent Stem Cells and Skeletal Regeneration--Promise and Potential.
Pluripotent Stem Cells and Skeletal Regeneration--Promise and Potential.
复制标题
DOI：
10.1007/s11914-015-0285-9
复制
发表时间：
2015-10
影响因子：
4.3
通讯作者：
Wu JY
中科院分区：
文献类型：
--
作者：
Wu JY
骨是一种再生组织，能够在骨折后自行愈合。然而，某些情况下，如临界尺寸缺陷，畸形和肿瘤破坏可能超过骨骼的自我修复能力。此外，骨量和强度随着年龄的增长而下降，导致脆性骨折增加。因此，产生大量患者特异性成骨细胞的能力将对骨骼缺陷和疾病的治疗具有巨大的临床意义。本文将重点介绍多能干细胞的来源及其向成骨细胞定向分化的最新进展。
Bone is a regenerative tissue, capable of healing itself after fractures. However, some circumstances such as critical size defects, malformations, and tumor destruction may exceed the skeleton’s capacity for self-repair. In addition, bone mass and strength decline with age, leading to an increase in fragility fractures. Therefore the ability to generate large numbers of patient-specific osteoblasts would have enormous clinical implications for the treatment of skeletal defects and diseases. This review will highlight recent advances in the derivation of pluripotent stem cells, and in their directed differentiation towards bone-forming osteoblasts.