The miR-24-Bim pathway promotes tumor growth and angiogenesis in pancreatic carcinoma.
The miR-24-Bim pathway promotes tumor growth and angiogenesis in pancreatic carcinoma.
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miR-24-Bim 通路促进胰腺癌肿瘤生长和血管生成
DOI：
10.18632/oncotarget.6257
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发表时间：
2015-12-22
期刊：
影响因子：
--
通讯作者：
Ba Y
中科院分区：
文献类型：
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作者：
Liu R;Zhang H;Wang X;Zhou L;Li H;Deng T;Qu Y;Duan J;Bai M;Ge S;Ning T;Zhang L;Huang D;Ba Y
miRNA是一组小的RNA，据报道在肿瘤发生的每个阶段都起着关键作用，并且据信具有未来的实用价值。我们现在证明，刺激细胞凋亡的BIM在胰腺癌（PAC）组织和细胞系中显然被下调。在PAC中，与BIM相关的miR-24显着上调。 BIM的抑制表达被证明是miR-24的结果，从而促进了癌症和血管细胞的细胞生长，并加速了血管环的形成。通过使用小鼠肿瘤模型，我们清楚地表明，miR-24通过抑制体内BIM表达促进肿瘤的生长和血管生成。因此，包括miR-24和BIM的新途径可用于探索PAC的药物目标治疗。
miRNAs are a group of small RNAs that have been reported to play a key role at each stage of tumorigenesis and are believed to have future practical value. We now demonstrate that Bim, which stimulates cell apoptosis, is obviously down-regulated in pancreatic cancer (PaC) tissues and cell lines. And Bim-related miR-24 is significantly up-regulated in PaC. The repressed expression of Bim is proved to be a result of miR-24, thus promoting cell growth of both cancer and vascular cells, and accelerating vascular ring formation. By using mouse tumor model, we clearly showed that miR-24 promotes tumor growth and angiogenesis by suppressing Bim expression in vivo. Therefore, a new pathway comprising miR-24 and Bim can be used in the exploration of drug-target therapy of PaC.