Sensitivity of bronchoprovocation and tracheal mucous velocity in detecting airway responses to O3.
Sensitivity of bronchoprovocation and tracheal mucous velocity in detecting airway responses to O3.
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支气管激发和气管粘液速度检测气道对 O3 反应的敏感性。
DOI：
10.1152/jappl.1980.48.5.789
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
Sackner,MA
中科院分区：
文献类型：
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作者：
Abraham,WM;Januszkiewicz,AJ;Mingle,M;Welker,M;Wanner,A;Sackner,MA
本研究的目的是确定气管粘液速度或气道对吸入卡巴胆碱的反应性的测量是否可以更灵敏地检测吸入臭氧 (O3) 对清醒羊的气道影响。卡巴胆碱的平均肺流阻 (RL) 的剂量反应曲线是通过在五次呼吸卡巴胆碱气雾剂后随着药物浓度逐步增加测量 RL 来获得的。然后动物通过气管导管呼吸 0.5 ppm O3 2 小时。 0.5 ppm O3 暴露后立即和 24 小时后重复剂量反应曲线。在研究的八只羊中，0.5 ppm O3 后立即或 24 小时后基线 RL 没有显着变化。绵羊吸入 0.5 ppm O3 后，气道高反应性并不立即明显，但 24 小时后就明显了。相比之下，六只羊以相同方式呼吸 0.5 ppm O3 2 小时，当天或 24 小时后气管粘液流速并未出现明显下降。暴露于 1 ppm O3 2 小时会导致暴露后立即出现气道高反应性，并在 24 小时后导致基线 RL 升高； 2 ppm O3 暴露后立即导致基线 RL 增加。我们的结论是，在有意识的绵羊中，气道高反应性似乎是短期暴露于 0.5 ppm O3 所产生的气道影响比气管粘液速度降低更敏感的指标。
This study was undertaken to determine whether measurements of tracheal mucous velocity or airway reactivity to inhaled carbachol more sensitively detect airway effects of inhaled ozone (O3) in conscious sheep. Dose-response curves of mean pulmonary flow resistance (RL) to carbachol were obtained by measuring RL after five breaths of carbachol aerosol with stepwise increases in drug concentration. The animals then breathed 0.5 ppm O3 through an endotracheal tube for 2 h. The dose-response curves were repeated immediately after the 0.5 ppm O3 exposure and 24 h later. In the eight sheep studied, there were no significant alterations in base-line RL immediately after or 24 h after 0.5 ppm O3. Airway hyperreactivity was not apparent immediately after the sheep breathed 0.5 ppm O3, but it was evident 24 h later. In contrast, six sheep that breathed 0.5 ppm O3 in the same manner for 2 h did not show a significant depression in tracheal mucous velocity the same day or 24 h later. Exposure to 1 ppm O3 for 2 h resulted in airway hyperreactivity immediately after the exposure and elevated base-line RL 24 h later; 2 ppm O3 produced an increase in base-line RL immediately after exposure. We conclude that, in conscious sheep, airway hyperreactivity appears to be a more sensitive indicator of airway effects produced by short-term exposure to 0.5 ppm O3 than depression of tracheal mucous velocity.