Occupational exposure to high molecular weight allergens and lymphoma risk among Italian adults.
Occupational exposure to high molecular weight allergens and lymphoma risk among Italian adults.
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DOI：
10.1158/1055-9965.epi-09-0446
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发表时间：
2009-10
期刊：
影响因子：
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通讯作者：
Vineis P
中科院分区：
文献类型：
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作者：
Mirabelli MC;Zock JP;D'Errico A;Kogevinas M;de Sanjosé S;Miligi L;Seniori Costantini A;Vineis P
暴露于高分子量(HMW)变应原，通过免疫球蛋白E(IgE)介导的途径激发免疫反应，与降低B细胞淋巴瘤的风险有关。目前的分析是为了评估职业暴露于特定HMW变应原与B细胞、T细胞和霍奇金淋巴瘤风险之间的关系。我们分析了1991年至1993年在意大利进行的一项多中心血液淋巴系统恶性肿瘤研究中登记的2290例淋巴瘤病例和1771名以人群为基础的对照组的数据。所有病例均经组织学或细胞学证实。对照组与基于年龄、性别和研究中心的病例频率匹配。一位工业卫生师在将哮喘特定工作暴露矩阵应用于参与者的工作历史后，对HMW职业暴露分类进行了评估。非条件Logistic回归用于评估淋巴瘤确诊前10年发生的≥职业暴露与B细胞、T细胞和霍奇金淋巴瘤之间的关系。10%的病例和11%的对照组在职业上接触到HMW过敏原。暴露者患所有淋巴瘤的风险降低(优势比(OR)：0.78，95%可信区间(CI)：0.63，0.97)，尤其是B细胞淋巴瘤(OR：0.75，95%CI：0.59，0.94)。当HMW变应原暴露于动物和乳胶变应原时，也观察到所有淋巴瘤的风险降低。这些发现支持这样一种假设，即职业性暴露于免疫活性HMW变应原与患淋巴瘤的风险成反比。暴露于特定过敏原的影响需要进一步评估。
Exposure to high molecular weight (HMW) allergens that provoke immune reactivity through an immunoglobulin E (IgE)-mediated pathway has been associated with a decreased risk of B-cell lymphoma. The present analysis was conducted to assess the associations between occupational exposure to specific HMW allergens and the risk of B-cell, T-cell, and Hodgkin's lymphomas. We analyzed data from 2290 incident lymphoma cases and 1771 population-based controls enrolled in a multi-center study of hematolymphopoietic malignancies conducted in Italy between 1991 and 1993. All cases were histologically or cytologically confirmed. Controls were frequency-matched to cases based on age, sex, and study center. An industrial hygienist evaluated HMW occupational exposure classifications after an asthma-specific job exposure matrix was applied to participants' job histories. Unconditional logistic regression was used to assess associations between occupational exposures that occurred ≥10 years before the date of lymphoma diagnosis and B-cell, T-cell, and Hodgkin's lymphomas. Ten percent of cases and 11 percent of controls were occupationally exposed to HMW allergens. Exposed individuals had a decreased risk for all lymphomas combined (odds ratio (OR): 0.78, 95% confidence interval (CI): 0.63, 0.97), particularly for B-cell lymphomas (OR: 0.75, 95% CI: 0.59, 0.94). The decreased risks for all lymphomas were also observed when HMW allergen exposure was limited to animal and latex allergens. These findings support the hypothesis that occupational exposure to immunologically active HMW allergens is inversely associated with the risk for lymphoma. The effect of exposure to specific allergens warrants further assessment.