Different Characteristics and Heritabilities of Alcohol Use Disorder Classes: A Population-Based Swedish Study.
Different Characteristics and Heritabilities of Alcohol Use Disorder Classes: A Population-Based Swedish Study.
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酒精使用障碍类别的不同特征和遗传力：一项基于人群的瑞典研究。
DOI：
10.1093/alcalc/agz069
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Kendler,KS
中科院分区：
文献类型：
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作者：
Long,EC;Ohlsson,H;Sundquist,J;Sundquist,K;Kendler,KS
AimsThe本研究的目的是确定酒精使用障碍（AUD）类之间的人口为基础的瑞典样本，确定这些类不同的变量已知与AUD和确定是否有一些AUD类具有较强的遗传影响比others.MethodsA潜在类分析（LCA），基于类型的登记，在出生于1960年至1990年之间的AUD登记的瑞典人（N= 184，770）中进行。这些类别，然后验证使用人口统计学;与药物滥用，精神疾病和犯罪行为的共病模式;和邻里水平的因素，即同伴AUD和邻里剥夺。遗传和环境的影响程度也investigated.ResultsThe最佳拟合LCA有四个类：（a）门诊/处方，其特征在于门诊医疗和处方登记的混合，（B）低频住院，其特征完全在于住院医疗登记，大多数个人具有一种AUD登记，（c）高频混合，其特征在于所有四种登记类型的混合，大多数有四次或四次以上的登记;（d）犯罪，其特点几乎完全是刑事登记。最高的遗传性为男性和女性被发现为3级（61%和65%，分别）和最低的1级（20%，两者），与共享的环境影响占10%或更少的方差在所有Classs.ConclusionsUsing全面的，全国范围内的登记数据，我们显示了证据，四个不同的，有意义的类的AUD具有不同程度的遗传性。
AimsThe aims of the present study are to identify alcohol use disorder (AUD) classes among a population-based Swedish sample, determine if these classes differ by variables known to be associated with AUD and determine whether some AUD classes have stronger genetic influences than others.MethodsA latent class analysis (LCA), based on types of registrations, was conducted on Swedish individuals with an AUD registration born between 1960 and 1990 (N= 184,770). These classes were then validated using demographics; patterns of comorbidity with drug abuse, psychiatric disorders and criminal behavior; and neighborhood-level factors, i.e. peer AUD and neighborhood deprivation. The degree of genetic and environmental influence was also investigated.ResultsThe best-fit LCA had four classes: (a) outpatient/prescription, characterized by a mix of outpatient medical and prescription registrations, (b) low-frequency inpatient, characterized entirely by inpatient medical registrations, with the majority of individuals having one AUD registration, (c) high-frequency mixed, characterized by a mix of all four registration types, with the majority having four or more registrations and (d) crime, characterized almost entirely by criminal registrations. The highest heritability for both males and females was found for Class 3 (61% and 65%, respectively) and the lowest for Class 1 (20% for both), with shared environmental influences accounting for 10% or less of the variance in all Classes.ConclusionsUsing comprehensive, nationwide registry data, we showed evidence for four distinct, meaningful classes of AUD with varying degrees of heritability.