Predicting response to benzamide riboside chemotherapy in hepatocellular carcinoma using apparent diffusion coefficient of water.
Predicting response to benzamide riboside chemotherapy in hepatocellular carcinoma using apparent diffusion coefficient of water.
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发表时间：
2011-06
影响因子：
2
通讯作者：
A. Babsky;S. Ju;B. George;S. Bennett;Mingsheng Huang;H. Jayaram;G. McLennan;N. Bansal
中科院分区：
文献类型：
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作者：
A. Babsky;S. Ju;B. George;S. Bennett;Mingsheng Huang;H. Jayaram;G. McLennan;N. Bansal
目的观察凋亡剂苯甲酰胺核苷(BR)对大鼠肝细胞癌肿瘤体积和水表观扩散系数(ADC)的影响。材料与方法采用弥散加权1H磁共振成像(DWI)测量肿瘤及癌旁肝组织的水ADC值。BR处理的两组动物对治疗的敏感性不同，被鉴定为反应性(RBR)和无反应性(NRBR)。结果治疗后第7天和第14天，RBR组肿瘤生长明显受阻，平均肿瘤体积分别为NRBR组的1/6和1/16。肝细胞癌的水ADC值高于邻近正常肝组织。在BR治疗前，RBR组的平均水ADC显著高于NRBR组。BR治疗不改变水的ADC值，与肿瘤的敏感性无关。结论虽然BR化疗后水ADC无明显变化，但DWI在检测和预测肝细胞癌化疗疗效方面具有很大的潜力。
AIM To monitor the effects of the apoptotic agent benzamide riboside (BR) on tumor volume and water apparent diffusion coefficient (ADC) in rat hepatocellular carcinoma (HCC). MATERIALS AND METHODS Water ADC of the tumors and nearby liver tissue was measured using diffusion-weighted 1H MRI (DWI). The two groups of BR-treated animals, which differed in their sensitivity to the treatment, were identified as responsive (RBR) and non-responsive (NRBR). RESULTS Tumor growth in the RBR group was arrested and the mean tumor volume in this group was 1/6th and 1/16th compared to that of the NRBR group on days 7 and 14 after treatment, respectively. Water ADC of HCC was higher than in nearby normal liver tissue. Before BR treatment, the mean water ADC was significantly higher in the RBR group compared to the NRBR group. BR therapy did not change the water ADC value regardless of tumor sensitivity. CONCLUSION Although the water ADC did not change after chemotherapy by BR, DWI has great potential for detecting and predicting response to chemotherapy in HCC.