Bilateral Contrast-enhanced Dual-Energy Digital Mammography: Feasibility and Comparison with Conventional Digital Mammography and MR Imaging in Women with Known Breast Carcinoma
Bilateral Contrast-enhanced Dual-Energy Digital Mammography: Feasibility and Comparison with Conventional Digital Mammography and MR Imaging in Women with Known Breast Carcinoma
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DOI：
10.1148/radiol.12121084
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发表时间：
2013-03-01
期刊：
影响因子：
19.7
通讯作者：
Morris, Elizabeth A.
中科院分区：
文献类型：
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作者：
Jochelson, Maxine S.;Dershaw, D. David;Morris, Elizabeth A.
目的：为了确定进行双边双能（DE）造影剂增强（CE）数字乳腺X射线摄影的可行性，并评估其性能与传统的数字乳腺X射线摄影和乳腺磁共振（MR）成像在女性已知的breastcancer.Materials和方法：这项研究是由机构审查委员会批准，并符合健康保险及责任法案。获得了书面知情同意书。患者招募从2010年3月开始，到2011年8月结束。患者平均年龄为49.6岁（范围：25-74岁）。在10名新诊断的乳腺癌女性中评估了可行性，这些女性注射了1.5 mL/kg体重的碘海醇，并在注射后2.5 - 10分钟内成像。一旦可行性得到确认，52名接受过乳腺MR成像的新诊断癌症的女性同意接受DE CE数字乳腺X射线摄影。结果：证实了该方法的可行性，无不良反应。造影剂注射后10分钟内，肿瘤增强的可视化与时间无关。MR成像和DE CE数字乳腺X线摄影均描绘了52个指数肿瘤中的50个（96%）;常规乳腺X线摄影描绘了42个（81%）。使用DE CE数字乳腺X线摄影描绘的病变大小范围为4至67 mm（中位数，17 mm）。DE CE数字乳腺X线摄影显示了25例额外同侧癌症中的14例（56%），而MR成像显示了25例额外同侧癌症中的22例（88%）。DE CE数字化乳腺摄影有2例假阳性结果，MR成像有13例假阳性结果。有一个对侧的癌症，这是不明显的model.Conclusion：双边DE CE数字乳腺摄影是可行的，容易实现。它用于检测已知的原发性肿瘤，其检测率与MR成像相当，高于传统的数字乳腺X线摄影。DE CE数字化乳腺X线摄影检测其他同侧癌症的敏感性低于MR成像，但特异性较高。(C)RSNA，2012年
Purpose: To determine feasibility of performing bilateral dual-energy (DE) contrast agent-enhanced (CE) digital mammography and to evaluate its performance compared with conventional digital mammography and breast magnetic resonance (MR) imaging in women with known breast cancer.Materials and Methods: This study was approved by the institutional review board and was HIPAA compliant. Written informed consent was obtained. Patient accrual began in March 2010 and ended in August 2011. Mean patient age was 49.6 years (range, 25-74 years). Feasibility was evaluated in 10 women with newly diagnosed breast cancer who were injected with 1.5 mL per kilogram of body weight of iohexol and imaged between 2.5 and 10 minutes after injection. Once feasibility was confirmed, 52 women with newly diagnosed cancer who had undergone breast MR imaging gave consent to undergo DE CE digital mammography. Positive findings were confirmed with pathologic findings.Results: Feasibility was confirmed with no adverse events. Visualization of tumor enhancement was independent of timing after contrast agent injection for up to 10 minutes. MR imaging and DE CE digital mammography both depicted 50 (96%) of 52 index tumors; conventional mammography depicted 42 (81%). Lesions depicted by using DE CE digital mammography ranged from 4 to 67 mm in size (median, 17 mm). DE CE digital mammography depicted 14 (56%) of 25 additional ipsilateral cancers compared with 22 (88%) of 25 for MR imaging. There were two false-positive findings with DE CE digital mammography and 13 false-positive findings with MR imaging. There was one contralateral cancer, which was not evident with either modality.Conclusion: Bilateral DE CE digital mammography was feasible and easily accomplished. It was used to detect known primary tumors at a rate comparable to that of MR imaging and higher than that of conventional digital mammography. DE CE digital mammography had a lower sensitivity for detecting additional ipsilateral cancers than did MR imaging, but the specificity was higher. (C) RSNA, 2012