Stimulation of bone formation in vitro and in rodents by statins
Stimulation of bone formation in vitro and in rodents by statins
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DOI：
10.1126/science.286.5446.1946
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发表时间：
1999-12-03
期刊：
影响因子：
56.9
通讯作者：
Gutierrez, G
中科院分区：
文献类型：
--
作者：
Mundy, G;Garrett, R;Gutierrez, G
骨质疏松症和其他骨质流失疾病是一个主要的公共卫生问题。在这里，它表明，他汀类药物，药物广泛用于降低血清胆固醇，也促进新骨形成在体外和啮齿动物。这种作用与骨细胞中骨形态发生蛋白-2（BMP-2）基因表达增加有关。洛伐他汀和辛伐他汀增加骨形成时，皮下注射超过小鼠的颅骨和增加松质骨体积时，口服给药大鼠。因此，在适当的剂量下，他汀类药物可用于治疗骨质疏松症。
Osteoporosis and other diseases of bone Loss are a major public health problem. Here it is shown that the statins, drugs widely used for Lowering serum cholesterol, also enhance new bone formation in vitro and in rodents. This effect was associated with increased expression of the bone morphogenetic protein-2 (BMP-2) gene in bone cells. Lovastatin and simvastatin increased bone formation when injected subcutaneously over the calvaria of mice and increased cancellous bone volume when orally administered to rats. Thus, in appropriate doses, statins may have therapeutic applications for the treatment of osteoporosis.