Direct evidence for expression of dopamine receptors in astrocytes from basal ganglia
Direct evidence for expression of dopamine receptors in astrocytes from basal ganglia
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DOI：
10.1016/j.brainres.2004.09.014
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发表时间：
2004-12-10
期刊：
影响因子：
2.9
通讯作者：
Ogawa, N
中科院分区：
文献类型：
--
作者：
Miyazaki, I;Asanuma, M;Ogawa, N
利用原代培养的星形胶质细胞和大鼠基底节区脑切片，在体外和体内检测了多巴胺受体（DA-Rs）在星形胶质细胞中的表达。基底神经节星形胶质细胞表达DA D1-、D3-、D4-和d5受体，并参与D4介导的信号转导，提示星形胶质细胞可能参与非典型抗精神病药物的药理作用和一些神经系统疾病的DA反应。(C) 2004 Elsevier B.V.版权所有
Expression of dopamine receptors (DA-Rs) in astrocytes was examined in vitro and in vivo using primary cultured astrocytes and brain slices from rat basal ganglia. Astrocytes from basal ganglia expressed DA D1-, D3-, D4- and D5-receptors and D4-mediated signal transduction in response to DA, suggesting possible involvement of astrocytes in the pharmacological action of atypical antipsychotic drugs and in DA response in some neurological diseases. (C) 2004 Elsevier B.V. All rights reserved.