Direct Solvent-Free Regioselective Construction of Pyrrolo[1,2-a][1,10]phenanthrolines Based on Isocyanide-Based Multicomponent Reactions
Direct Solvent-Free Regioselective Construction of Pyrrolo[1,2-a][1,10]phenanthrolines Based on Isocyanide-Based Multicomponent Reactions
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基于异氰化物多组分反应直接无溶剂区域选择性构建吡咯并[1,2-a][1,10]菲咯啉
DOI：
10.1021/ol400191b
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发表时间：
2013-03-15
期刊：
影响因子：
5.2
通讯作者：
Hu, Zhi-Qiang
中科院分区：
文献类型：
--
作者：
Li, Ming;Lv, Xiu-Liang;Hu, Zhi-Qiang
通过醛、丙二腈、异氰化物与1，10-菲咯啉的1，3-偶极环加成反应，在无溶剂条件下，不使用任何催化剂或活化，在3min内实现了一锅四组分区域选择性合成吡咯并[1，2-a][1，10]菲咯啉。初步考察了产物作为Cu2+的显色和荧光传感器的性能。
A novel efficient one-pot four-component regioselective synthesis of pyrrolo[1,2-a][1,10]phenanthrolines in excellent yields has been developed by 1,3-dipolar cycloaddition of aldehydes, malononitrile, and isocyanides with 1,10-phenanthroline under solvent-free conditions within 3 min without using any catalyst or activation. The products were preliminarily investigated as chromogenic and fluorescent sensors for Cu2+ ions.