(13)C-labeled biochemical probes for the study of cancer metabolism with dynamic nuclear polarization-enhanced magnetic resonance imaging.
(13)C-labeled biochemical probes for the study of cancer metabolism with dynamic nuclear polarization-enhanced magnetic resonance imaging.
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DOI：
10.1186/s40170-015-0136-2
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发表时间：
2015
影响因子：
5.9
通讯作者：
Keshari KR
中科院分区：
文献类型：
--
作者：
Salamanca-Cardona L;Keshari KR
近年来，代谢成像的进展已成为癌症诊断和治疗评估的可靠工具。动态核极化（DNP）最近成为超极化（HP）磁共振成像（MRI）的一项有前途的技术，随着[1-13C]丙酮酸作为人类前列腺癌分子成像探针的成功可视化，DNP已达到临床应用价值。本文重点介绍了与肿瘤组织代谢相关的代表性化合物：有氧糖酵解和丙酮酸代谢，谷氨酰胺成瘾和谷氨酰胺/谷氨酸代谢，氧化还原状态和抗坏血酸/脱氢抗坏血酸代谢。此外，本文还简要介绍了可用于追踪坏死、pH值变化和其他与癌症相关的途径的探针，以证明HP MRI有可能彻底改变分子成像在癌症诊断和治疗评估中的应用。
In recent years, advances in metabolic imaging have become dependable tools for the diagnosis and treatment assessment in cancer. Dynamic nuclear polarization (DNP) has recently emerged as a promising technology in hyperpolarized (HP) magnetic resonance imaging (MRI) and has reached clinical relevance with the successful visualization of [1-13C] pyruvate as a molecular imaging probe in human prostate cancer. This review focuses on introducing representative compounds relevant to metabolism that are characteristic of cancer tissue: aerobic glycolysis and pyruvate metabolism, glutamine addiction and glutamine/glutamate metabolism, and the redox state and ascorbate/dehydroascorbate metabolism. In addition, a brief introduction of probes that can be used to trace necrosis, pH changes, and other pathways relevant to cancer is presented to demonstrate the potential that HP MRI has to revolutionize the use of molecular imaging for diagnosis and assessment of treatments in cancer.