Evaluation of the release profile, stability and antioxidant activity of a proanthocyanidin-rich cinnamon (Cinnamomum zeylanicum) extract co-encapsulated with α-tocopherol by spray chilling.
Evaluation of the release profile, stability and antioxidant activity of a proanthocyanidin-rich cinnamon (Cinnamomum zeylanicum) extract co-encapsulated with α-tocopherol by spray chilling.
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DOI：
10.1016/j.foodres.2017.03.010
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发表时间：
2017-05
影响因子：
8.1
通讯作者：
F. Tulini;V. B. Souza;M. Thomazini;M. P. Silva;A. Massarioli;S. M. Alencar;E. Pallone;M. Genovese;C. Fávaro-Trindade
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文献类型：
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作者：
F. Tulini;V. B. Souza;M. Thomazini;M. P. Silva;A. Massarioli;S. M. Alencar;E. Pallone;M. Genovese;C. Fávaro-Trindade
肉桂有许多改善健康的化合物，如原花青素，这也有可能预防糖尿病造成的损害。同样，α-生育酚是一种天然抗氧化剂，对保护膜和脂蛋白中的脂肪酸具有重要作用。然而，在食品中添加抗氧化剂可能会导致与食品基质相互作用，稳定性低，味道不好。采用喷雾冷冻法将富含原花青素的肉桂提取物（PRCE）与α-生育酚（α-tocopherol）共包埋于固体脂质微粒（SLMs）中。微粒的物理和化学性质，形态，原花青素的稳定性和释放曲线方面进行了表征。SLMs呈球形，平均直径约80 μm。原花青素在5、25和37 °C下储存长达90天的SLM中高度稳定。此外，SLMs逐渐释放原花青素在模拟胃肠液中的扩散过程，Korsmeyer-Peppas动力学。抗氧化成分的分析表明，PRCE组分对活性氧（ROS）和活性氮（RNS）表现出较高的清除能力。因此，本研究制备的SLMs具有开发新型功能性食品和营养保健品的潜力，也为原花青素和α-生育酚在肠道中的控释提供了一种选择。
Cinnamon has many health improving compounds such as proanthocyanidins, which also have potential for the prevention of damages caused by diabetes. Similarly, α-tocopherol is a natural antioxidant with important role on protection of fatty acids in membranes and lipoproteins. However, the addition of antioxidants in food may result in interaction with food matrix, low stability and unpleasant taste. In the present study, a proanthocyanidin-rich cinnamon extract (PRCE) (Cinnamomum zeylanicum) was co-encapsulated with α-tocopherol into solid lipid microparticles (SLMs) by spray chilling. The microparticles were characterized with regard to the physical and chemical properties, morphology, proanthocyanidin stability and release profile. SLMs were spherical with an average diameter ofca.80 μm. Proanthocyanidins were highly stable in SLMs stored for up to 90 days at 5, 25 and 37 °C. Moreover, SLMs gradually released proanthocyanidins in simulated gastrointestinal fluids by a diffusional process, following a Korsmeyer-Peppas kinetic. Analyses of the antioxidant compounds indicated that PRCE components exhibited a higher scavenging capacity against reactive oxygen species (ROS) and reactive nitrogen species (RNS). Thus, the SLMs produced in the present study have potential for application in the development of new functional foods and nutraceuticals, also providing an alternative for the controlled release of proanthocyanidins and α-tocopherol into the intestine.