Cortical Thickness, Cortico-Amygdalar Networks, and Externalizing Behaviors in Healthy Children
Cortical Thickness, Cortico-Amygdalar Networks, and Externalizing Behaviors in Healthy Children
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DOI：
10.1016/j.biopsych.2013.06.008
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发表时间：
2014-01-01
影响因子：
10.6
通讯作者：
Karama, Sherif
中科院分区：
文献类型：
--
作者：
Ameis, Stephanie H.;Ducharme, Simon;Karama, Sherif
背景资料：额杏仁核网络与儿童精神障碍有关，其特征是高比例的外化（攻击性，不顺从，对立）行为。尽管外化行为在临床和非临床样本中连续分布，但人们对大脑变异如何导致问题行为的风险知之甚少。在这里，我们研究了皮质厚度，杏仁核体积，皮质-杏仁核网络相关的外化behaviors.Methods：297名健康儿童（6-18岁，平均12 +/- 3年），517磁共振成像扫描，从美国国立卫生研究院正常大脑发育的磁共振成像研究，进行了研究。在控制年龄、性别、扫描仪和总脑体积后，使用一阶线性混合效应模型研究了外化行为（用儿童行为检查表测量）与皮质厚度、杏仁核体积和皮质-杏仁核结构网络之间的关系。结果在p
Background: Fronto-amygdalar networks are implicated in childhood psychiatric disorders characterized by high rates of externalizing (aggressive, noncompliant, oppositional) behavior. Although externalizing behaviors are distributed continuously across clinical and nonclinical samples, little is known about how brain variations may confer risk for problematic behavior. Here, we studied cortical thickness, amygdala volume, and cortico-amygdalar network correlates of externalizing behavior in a large sample of healthy children.Methods: Two hundred ninety-seven healthy children (6-18 years; mean 12 +/- 3 years), with 517 magnetic resonance imaging scans, from the National Institutes of Health Magnetic Resonance Imaging Study of Normal Brain Development, were studied. Relationships between externalizing behaviors (measured with the Child Behavior Checklist) and cortical thickness, amygdala volume, and cortico-amygdalar structural networks were examined using first-order linear mixed-effects models, after controlling for age, sex, scanner, and total brain volume. Results significant at p