Regulation of Toll-like receptor signaling pathways in innate immune responses
Regulation of Toll-like receptor signaling pathways in innate immune responses
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先天免疫反应中 Toll 样受体信号通路的调节
DOI：
10.1111/j.1749-6632.2012.06786.x
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发表时间：
2013-01-01
期刊：
影响因子：
--
通讯作者：
Cao, Xuetao
中科院分区：
文献类型：
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作者：
Qian, Cheng;Cao, Xuetao
Toll样受体(Toll-like Receptor，TLRs)是识别病原体相关分子模式(PAMPs)的关键模式识别受体，PAMPs是病原体表达的保守的、特定的分子“信号”。TLR结扎触发不同但共享的信号通路，从而导致先天免疫反应中的效应机制。TLR的特异性和激活在不同的信号转导途径的多个水平上被严格和精细地调节，导致了复杂的信号平台。从细胞膜、胞浆到细胞核，许多分子参与TLR的配体识别或受体信号传递，并通过不同的机制在TLR反应的调节中发挥不同的作用，如交叉调节、蛋白质修饰、辅助辅助因子以及转录后和表观遗传调节。在此，我们总结了最新的文献，这些文献为TLR信号触发的先天性免疫反应的调控提供了新的见解。进一步了解控制TLR信号的机制可能为感染和炎症性疾病的治疗干预提供新的靶点。
Toll-like receptors (TLRs) are critical pattern recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs), which are conserved and specific molecular "signatures" expressed by pathogens. TLR ligation triggers distinct but shared signaling pathways that lead to effector mechanisms in innate immune responses. TLR specificity and activation are strictly and finely tuned at multiple levels of various signal transduction pathways, resulting in complex signaling platforms. Many molecules, ranging from membrane and cytosol to nuclear, contribute to TLR ligand discrimination or receptor signaling and play different roles in the regulation of TLR responses via different mechanisms, such as cross-regulation, protein modification, helper cofactors, and posttranscriptional and epigenetic regulation. Herein, we summarize the most recent literature that provides new insight into regulation of TLR signaling-triggered innate immune responses. A greater understanding of the mechanisms underlying the control of TLR signaling may provide new targets for therapeutic intervention for infections and inflammatory diseases.