CORE BODY-TEMPERATURE AND CIRCADIAN-RHYTHM OF HOT FLASHES IN MENOPAUSAL WOMEN
CORE BODY-TEMPERATURE AND CIRCADIAN-RHYTHM OF HOT FLASHES IN MENOPAUSAL WOMEN
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DOI：
10.1210/jc.80.8.2354
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发表时间：
1995-08-01
影响因子：
5.8
通讯作者：
CORNELISSEN, G
中科院分区：
文献类型：
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作者：
FREEDMAN, RR;NORTON, D;CORNELISSEN, G
绝经后潮热的特征是出汗和外周血管扩张，在热负荷增加时更频繁地发生。核心体温（T-C）的昼夜节律是众所周知的，并表明当核心温度最高时，潮热将最频繁。这一假设以前没有被检验过。10例有症状者：绝经后无症状者。妇女是从广告中招聘并经过筛选的。每个人都接受了24小时胸骨皮肤电导水平的动态监测，以检测潮热、环境温度、皮肤温度和T-C。最后一次测量是使用摄入的无线电遥测药丸记录的。Cosinor分析显示潮热具有昼夜节律（P < 0.02），高峰出现在1825 h左右。有症状妇女的T-C值在0000 - 0400 h、1500和2200 h低于无症状妇女（P <0.05）。大多数潮热发生前T-C升高。因此，T-C升高可能是绝经期潮热的一个触发因素。
Postmenopausal hot flashes are characterized by sweating and peripheral vasodilation and occur more frequently during increased heat loads. The circadian rhythm of core body temperature (T-C) is well known and suggests that hot flashes will be most frequent when core temperature is highest. This hypothesis has not been tested previously. Ten symptomatic and sis: asymptomatic postmenopausal. women were recruited from advertisements and screened. Each received 24-h ambulatory monitoring of sternal skin conductance levels to detect hot flashes, ambient temperature, skin temperature, and T-C. The last measure was recorded using an ingested radiotelemetry pill. Cosinor analysis demonstrated a circadian rhythm (P < 0.02) of hot flashes with a peak at about 1825 h. T-C values of the symptomatic women were lower than those of the asymptomatic women (P < .05) from 0000 - 0400 h and at 1500 and 2200 h. The majority of hot flashes were preceded by elevations in T-C. Thus, elevated T-C may serve as one trigger of menopausal hot flashes.