Relationship between arterial and portal vein immunoreactive glucagon during exercise.
Relationship between arterial and portal vein immunoreactive glucagon during exercise.
复制标题
运动期间动脉和门静脉免疫反应性胰高血糖素之间的关系。
DOI：
10.1152/jappl.1993.75.2.724
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Bracy,DP
中科院分区：
文献类型：
--
作者：
Wasserman,DH;Lacy,DB;Bracy,DP
运动期间胰高血糖素变化在调节肝葡萄糖生成 (Ra) 中的重要性受到质疑，因为动脉免疫反应性胰高血糖素 (IRG) 的增加并不总是可检测到。然而，门静脉 (PV) 中的 IRG 而不是动脉中的 IRG 最为相关，因为通过 PV 的流量约为肝脏血流量的 80%。为了评估动脉 IRG 反映 PV 中肝脏暴露水平的程度，狗 (n = 5) 在颈动脉、肝静脉 (HV) 和 PV 中植入了导管。 ≥ 16 天后，在休息和 150 分钟的适度跑步机运动期间对狗进行研究，注入吲哚菁绿和 [3-3H] 葡萄糖，以评估肝血浆流量 (HPF) 和肝 Ra。静息时动脉、HV 和 PV 中的 IRG 分别为 66 +/- 7、73 +/- 8 和 81 +/- 7 pg/ml；在运动 10 分钟和 150 分钟时，动脉中的血压升高至 89 +/- 9 和 127 +/- 13 pg/ml，HV 中升高至 106 +/- 17 和 186 +/- 21 pg/ml，PV 中升高得多，达到 153 +/- 20 和 261 +/- 25 pg/ml。运动后 HPF 下降约 30%。 HPF 的下降占运动期间动脉至 PV IRG 梯度增加的 < 11%，其余部分是内脏 IRG 释放的增加。 Ra 与三个血管中的 IRG 水平呈线性相关。（摘要截断为 250 字）
The importance of changes in glucagon in the regulation of hepatic glucose production (Ra) during exercise has been questioned, as an increase in arterial immunoreactive glucagon (IRG) is not always detectable. However, IRG in the portal vein (PV) and not in the artery is most relevant, as flow through PV is approximately 80% of liver blood flow. To assess the extent that arterial IRG reflects the levels the liver is exposed to in PV, dogs (n = 5) were implanted with catheters in a carotid artery, hepatic vein (HV), and PV. Dogs were studied > or = 16 days later during rest and 150 min of moderate treadmill exercise, with indocyanine green and [3–3H]glucose infused to assess hepatic plasma flow (HPF) and hepatic Ra. IRG was 66 +/- 7, 73 +/- 8, and 81 +/- 7 pg/ml in the artery, HV, and PV at rest; it rose at 10 and 150 min of exercise to 89 +/- 9 and 127 +/- 13 pg/ml in the artery, 106 +/- 17 and 186 +/- 21 pg/ml in HV, and, by considerably more, to 153 +/- 20 and 261 +/- 25 pg/ml in PV. HPF fell by approximately 30% with exercise. The fall in HPF accounted for < 11% of the increased arterial-to-PV IRG gradient during exercise, with increased splanchnic IRG release comprising the remainder. Ra was linearly related to IRG levels in the three vessels.(ABSTRACT TRUNCATED AT 250 WORDS)