Trend Analysis of Antimicrobial Resistance in Campylobacter jejuni and Campylobacter coli Isolated from Belgian Pork and Poultry Meat Products Using Surveillance Data of 2004-2009
Trend Analysis of Antimicrobial Resistance in Campylobacter jejuni and Campylobacter coli Isolated from Belgian Pork and Poultry Meat Products Using Surveillance Data of 2004-2009
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DOI：
10.1089/fpd.2011.1042
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发表时间：
2012-05-01
影响因子：
2.8
通讯作者：
Dierick, Katelijne
中科院分区：
文献类型：
--
作者：
Mattheus, Wesley;Botteldoorn, Nadine;Dierick, Katelijne
本研究的目的是分析和比较弯曲杆菌的耐药性。使用2004-2009年期间的可用监测数据，从比利时的猪肉和家禽尸体以及猪肉和家禽肉（屠宰场水平、切肉过程和零售）中分离出。用E-test法测定了1724株弯曲杆菌对氨苄青霉素、环丙沙星、萘啶酸、四环素、红霉素和庆大霉素的敏感性。直到2007年，庆大霉素耐药性都很低（接近0%），到2009年，所有种属-基质组合的耐药性都增加到20%以上。在整个研究期间，对四环素的抗性在相同水平上下波动，并且在C中显著更高（p值< 0.05）。coli中比C.空肠。红霉素耐药性较低，2004年至2007年略有下降，但从2007年到2009年有所增加。与猪肉相关分离株相比，来自家禽的分离株对氟喹诺酮和氨苄青霉素的耐药性显著较高。这与家禽饲养业中这些抗菌剂的使用量较高有关。C.来自家禽的大肠杆菌分离株表现出最明显的多重耐药性（对四种或更多种抗菌剂的耐药性）。约1%的禽源分离株（包括C。coli和C.空肠）对所有测试的抗菌剂都显示出耐药性，而猪肉产品中没有发现耐药性。
The purpose of this study was to analyze and compare antimicrobial resistance in Campylobacter spp. isolated from pork and poultry carcasses, and pork and poultry meat (at slaughterhouse level, during meat cutting, and at retail) in Belgium, using available surveillance data over the period 2004-2009. The susceptibilities of 1724 Campylobacter isolates for ampicillin, ciprofloxacin, nalidixic acid, tetracycline, erythromycin, and gentamicin were tested by E-test. Gentamicin resistance was low (near 0%) until 2007, with an increase to over 20% by 2009 for all species-matrix combinations. Resistance to tetracycline fluctuated around the same level during the entire study period and was significantly higher (p-value of < 0.05) in C. coli than in C. jejuni. Erythromycin resistance was low and showed a slight decrease between 2004 and 2007, but increased from 2007 until 2009. Fluoroquinolone and ampicillin resistance was significantly higher in isolates derived from poultry, compared to pork-related isolates. This correlates with the higher use of these antimicrobials in poultry husbandry. A total of 25% of C. coli isolates from poultry showed the most apparent multiresistance (resistance to four or more antimicrobials). Approximately 1% of the poultry-derived isolates (both C. coli and C. jejuni) showed resistance to all tested antimicrobials, while none was found in pork products.