The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes
The 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia: rationale and important changes
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DOI：
10.1182/blood-2009-03-209262
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发表时间：
2009-07-30
期刊：
影响因子：
20.3
通讯作者：
Bloomfield, Clara D.
中科院分区：
文献类型：
--
作者：
Vardiman, James W.;Thiele, Juergen;Bloomfield, Clara D.
最近，世界卫生组织(世卫组织)与欧洲血液病理学协会和血液病理学学会合作，出版了世卫组织造血和淋巴组织肿瘤分类的修订版和更新版。世卫组织分类的第四版纳入了自2001年第三版出版以来在这段时间内从科学和临床研究中出现的新信息，并包括一些以前描述的肿瘤的识别新标准以及对其他肿瘤的定义标准的澄清和完善。它还增加了最近才被定性的实体--一些主要由遗传特征定义的实体。本文着重介绍髓系肿瘤和急性白血病的分类，目的是使血液学家、临床科学家和血液病理学家不仅熟悉分类中的主要变化，而且了解这些变化的基本原理。(血。2009；114：937-951)
Recently the World Health Organization (WHO), in collaboration with the European Association for Haematopathology and the Society for Hematopathology, published a revised and updated edition of the WHO Classification of Tumors of the Hematopoietic and Lymphoid Tissues. The 4th edition of the WHO classification incorporates new information that emerged from scientific and clinical studies in the interval since the publication of the 3rd edition in 2001, and includes new criteria for the recognition of some previously described neoplasms as well as clarification and refinement of the defining criteria for others. It also adds entities-some defined principally by genetic features-that have only recently been characterized. In this paper, the classification of myeloid neoplasms and acute leukemia is highlighted with the aim of familiarizing hematologists, clinical scientists, and hematopathologists not only with the major changes in the classification but also with the rationale for those changes. (Blood. 2009; 114: 937-951)