An elevated preoperative serum calcium level is a significant predictor for positive peritoneal cytology in endometrial carcinoma
An elevated preoperative serum calcium level is a significant predictor for positive peritoneal cytology in endometrial carcinoma
复制标题
术前血清钙水平升高是子宫内膜癌腹膜细胞学阳性的重要预测因素
DOI：
10.21147/j.issn.1000-9604.2019.06.12
复制
发表时间：
2019-12-01
影响因子：
5.1
通讯作者：
Wang, Jianliu
中科院分区：
文献类型：
--
作者：
Li, Xingchen;Cheng, Yuan;Wang, Jianliu
目的：评价子宫内膜癌（EC）术前血钙水平，探讨钙水平与腹膜细胞学阳性的关系。方法：2012年1月至2016年12月，北京大学人民医院首次纳入510例诊断为EC并进行手术治疗的患者。从患者病历中提取临床特征及术前血清钙、白蛋白、碳水化合物抗原（CA）125、CA19-9、癌胚抗原（CEA），并根据术后腹膜细胞学检查评估。采用Cox单因素和多因素分析评估预测因素。从多变量分析结果中选择因素建立预测模型。结果：在我们的数据库中共识别了510例患者，444例符合纳入和排除标准的患者被纳入本研究。单因素分析显示，离子钙浓度与腹膜细胞学阳性、肿瘤分级和淋巴血管间隙浸润（LVSI）密切相关。此外，腹膜细胞学与高血压、输卵管结扎、血清CA125、CA19-9、CEA和离子钙水平显著相关。多因素分析显示，白蛋白调节钙水平、CA125和输卵管结扎是腹膜细胞学阳性的独立预测因素(P
Objective: To evaluate preoperative serum calcium concentration and investigate the association between calcium level and positive peritoneal cytology in endometrial carcinoma (EC).Methods: A total of 510 patients who were diagnosed with EC and had surgery were initially enrolled in this study at Peking University People's Hospital between January 2012 and December 2016. Clinical characteristics and preoperative serum calcium, albumin, carbohydrate antigen (CA)125, CA19-9, carcinoembryonic antigen (CEA) were extracted from patient records and evaluated according to postoperative peritoneal cytology. Predictive factors were assessed with Cox univariate and multivariate analyses. Factors selected from multivariate analysis results were used to build a predictive model.Results: A total of 510 patients are identified in our database and 444 patients who fulfilled inclusion and exclusion criteria are included in this study. Univariate analysis revealed that ionized calcium concentration was closely related to positive peritoneal cytology, tumor grade and lymph-vascular space invasion (LVSI). Moreover, peritoneal cytology was significantly associated with hypertension, tubal ligation, serum CA125, CA19-9, CEA and ionized calcium level. Multivariate analysis revealed that albumin-adjusted calcium level, CA125 and tubal ligation were independent predictive factors of positive peritoneal cytology (P