Toward individual glomerular phenotyping: advent of precision medicine in kidney biopsies.
Toward individual glomerular phenotyping: advent of precision medicine in kidney biopsies.
复制标题
走向个体肾小球表型分析：肾活检精准医学的出现。
DOI：
10.1016/j.kint.2018.01.035
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发表时间：
2018
影响因子：
19.6
通讯作者：
Paša-Tolić,Ljiljana
中科院分区：
文献类型：
--
作者：
Sharma,Kumar;Paša-Tolić,Ljiljana
肾脏病精准医疗之路正在快速逼近。在本卷中，肾小球蛋白质组的特点是在一个单一的肾小球水平在小鼠和人类肾脏。使用单罐固相增强样品制备（SP3）方法，作者证明了LAMP1是一种关键的溶酶体蛋白，在肾小球疾病中增加，并可能发挥致病作用。
The road to precision medicine for nephrology is approaching quickly. In the present volume, the glomerular proteome has now been characterized at a single glomerulus level in mouse and human kidneys. Using the Single-Pot Solid-Phase–enhanced Sample Preparation (SP3) approach the authors demonstrated that LAMP1 is a key lysosomal protein that is increased in glomerular diseases and may play a pathogenic role.