Effect of sex hormone administration on circulating ghrelin levels in peripubertal children
Effect of sex hormone administration on circulating ghrelin levels in peripubertal children
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DOI：
10.1210/jc.2005-0204
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发表时间：
2006-01-01
影响因子：
5.8
通讯作者：
Lazar, L
中科院分区：
文献类型：
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作者：
Lebenthal, Y;Gat-Yablonski, G;Lazar, L
背景：生长素释放肽水平在整个儿童期和青春期阶段逐渐下降。男孩青春期的变化比女孩更明显。目的：本研究的目的是调查青春期生长素释放肽分泌量的下降是否会因性激素的增加而改变。患者和方法：在 GH 刺激测试的性激素启动前后，测量了 34 名 8-12.5 岁矮个子围青春期儿童（17 名男孩和 17 名女孩）的生长素释放肽水平。睾酮将睾酮水平提高至青春期水平（23.7 +/- 7.1 nmol/L），进而导致生长素释放肽（从 1615.8 +/- 418.6 到 1390.0 +/- 352.0 pg/ml）和瘦素（从 8.0 +/- 4.5 到 5.8 +/- 3.2 ng/ml）显着下降，并且IGF-I（从 162.7 +/- 52.8 到 291.1 +/- 101.6 ng/ml）（所有参数 P < 0.001）。在女孩中，雌激素引发导致雌二醇水平超生理性增加（1313.8+/-438.0pmol/升），这对生长素释放肽、瘦素或IGF-I没有影响。无论是男孩还是女孩，生长素释放肽水平与性激素、瘦素或体重指数水平之间均不存在相关性。结论：性激素药理学增加与男孩的生长素释放肽循环水平显着下降相关，但与女孩无关。需要在青春期进行额外的纵向研究来阐明性激素和生长素释放肽之间的生理相互作用。
Background: Ghrelin levels gradually decrease throughout childhood and with advancing pubertal stage. The change during puberty is more pronounced in boys than girls.Objective: The objective of the study was to investigate whether the pubertal drop in ghrelin secretion is modified by the increase in sex hormones.Patients and Methods: Ghrelin levels were measured in 34 short peripubertal children (17 boys and 17 girls) aged 8-12.5 yr before and after sex hormone priming for GH stimulation testing.Results: In boys, priming with testosterone increased testosterone to pubertal levels (23.7 +/- 7.1 nmol/liter), which in turn induced a marked decrease in ghrelin (from 1615.8 +/- 418.6 to 1390.0 +/- 352.0 pg/ml) and leptin (from 8.0 +/- 4.5 to 5.8 +/- 3.2 ng/ml) and an increase in IGF-I (from 162.7 +/- 52.8 to 291.1 +/- 101.6 ng/ml) (P < 0.001 for all parameters). In girls, priming with estrogen led to a supraphysiological increase in estradiol levels (1313.8 +/- 438.0 pmol/liter), which had no effect on ghrelin, leptin, or IGF-I. There was no correlation between ghrelin levels and levels of sex hormones, leptin, or body mass index in either boys or girls.Conclusions: A pharmacological increase in sex hormones is associated with a marked decline in circulating levels of ghrelin in boys but not girls. Additional longitudinal studies through puberty are needed to elucidate the physiological interaction between sex hormones and ghrelin.