Effect of female sex hormones on Campylobacter rectus and human gingival fibroblasts.
Effect of female sex hormones on Campylobacter rectus and human gingival fibroblasts.
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DOI：
10.1111/j.1399-302x.2005.00222.x
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发表时间：
2005-06
影响因子：
--
通讯作者：
M. Yokoyama;D. Hinode;K. Masuda;M. Yoshioka;D. Grenier
中科院分区：
文献类型：
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作者：
M. Yokoyama;D. Hinode;K. Masuda;M. Yoshioka;D. Grenier
最近的研究表明，母体直肠弯曲杆菌感染与早产低出生体重之间存在关系。本研究旨在探讨雌性性激素雌二醇和黄体酮对直梭菌和人牙龈成纤维细胞（HGF）的影响。在培养基中加入雌二醇或黄体酮均能显著促进直梭菌的生长。雌激素或黄体酮刺激后，HGF产生的血管内皮生长因子（VEGF）、白细胞介素(IL)-6和IL-8增加，其浓度与孕妇血浆中的浓度相当。此外，与单用直梭菌相比，直梭菌与雌二醇联合治疗HGF对VEGF的分泌明显增加。用VEGF刺激HGF导致IL-6和IL-8的产生呈剂量依赖性。女性性激素促进直梭菌生长和HGF产生VEGF、IL-6和IL-8的能力有可能促进妊娠期间牙周病的进展。
Recent studies have suggested a relationship between maternal Campylobacter rectus infections and preterm low birth weight. The purpose of this study was to investigate the effect of female sex hormones, estradiol and progesterone, on C. rectus and human gingival fibroblasts (HGF). The growth of C. rectus was significantly enhanced by incorporating either estradiol or progesterone in the culture medium. The production of vascular endothelial growth factor (VEGF), interleukin (IL)-6 and IL-8 by HGF increased following stimulation with estradiol or progesterone, at concentrations comparable to those present in the plasma of pregnant women. In addition, a significantly higher secretion of VEGF by HGF treated with the combination of C. rectus and estradiol was observed in comparison with a treatment with C. rectus alone. Stimulation of HGF with VEGF resulted in production of IL-6 and IL-8 in a dose-dependent manner. The capacity of female sex hormones to enhance both C. rectus growth and VEGF, IL-6, and IL-8 production by HGF has the potential to contribute to periodontal disease progression during pregnancy.