Application of neurite orientation dispersion and density imaging (NODDI) to a tau pathology model of Alzheimer's disease.
Application of neurite orientation dispersion and density imaging (NODDI) to a tau pathology model of Alzheimer's disease.
复制标题
神经突导向分散和密度成像（NODDI）应用于阿尔茨海默氏病的TAU病理模型。
DOI：
10.1016/j.neuroimage.2015.10.043
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发表时间：
2016-01-15
期刊：
影响因子：
5.7
通讯作者：
Lythgoe MF
中科院分区：
文献类型：
--
作者：
Colgan N;Siow B;O'Callaghan JM;Harrison IF;Wells JA;Holmes HE;Ismail O;Richardson S;Alexander DC;Collins EC;Fisher EM;Johnson R;Schwarz AJ;Ahmed Z;O'Neill MJ;Murray TK;Zhang H;Lythgoe MF
增加的过度磷酸化tau蛋白和细胞内神经元缠结的形成与阿尔茨海默病和相关神经退行性病症中的神经元损失和认知下降相关。我们应用两种扩散模型，扩散张量成像（DTI）和神经突方向弥散和密度成像（NODDI），在体内扩散磁共振成像（dMRI）的小鼠模型的人类tau蛋白病（rTg 4510）在8.5个月的年龄。在具有最高程度的tau负荷的灰质区域中，由NODDI和DTI两者提供的显微结构指数将rTg 4510（TG）动物与野生型（WT）对照区分开;然而，来自NODDI模型的仅神经突密度指数（NDI）（包括轴突或树突的体积分数）与过度磷酸化的tau蛋白水平的组织学测量相关。当在胼胝体的白色物质区域实施两种模型时，观察到扩散方向性的降低，在TG动物中观察到较低的各向异性分数（DTI）和较高的取向分散度（NODDI）。与DTI相比，tau病理学的组织学测量与该区域的NODDI参数更密切相关。这项体内dMRI研究表明，NODDI确定了潜在的组织来源，有助于DTI指数和NODDI可能提供更大的特异性，在阿尔茨海默病的病理。我们分析了rTg 4510和野生型小鼠在8.5个月时的显微结构变化。我们将显微结构发现与tau负荷的组织学测量相关联。我们比较了两种扩散MR模型：DTI和NODDI。两种模型都显示了由于tau病理学引起的组织微观结构的变化。NODDI指标显示与tau负荷的组织学测量具有良好的相关性。
Increased hyperphosphorylated tau and the formation of intracellular neurofibrillary tangles are associated with the loss of neurons and cognitive decline in Alzheimer's disease, and related neurodegenerative conditions. We applied two diffusion models, diffusion tensor imaging (DTI) and neurite orientation dispersion and density imaging (NODDI), to in vivo diffusion magnetic resonance images (dMRI) of a mouse model of human tauopathy (rTg4510) at 8.5 months of age. In grey matter regions with the highest degree of tau burden, microstructural indices provided by both NODDI and DTI discriminated the rTg4510 (TG) animals from wild type (WT) controls; however only the neurite density index (NDI) (the volume fraction that comprises axons or dendrites) from the NODDI model correlated with the histological measurements of the levels of hyperphosphorylated tau protein. Reductions in diffusion directionality were observed when implementing both models in the white matter region of the corpus callosum, with lower fractional anisotropy (DTI) and higher orientation dispersion (NODDI) observed in the TG animals. In comparison to DTI, histological measures of tau pathology were more closely correlated with NODDI parameters in this region. This in vivo dMRI study demonstrates that NODDI identifies potential tissue sources contributing to DTI indices and NODDI may provide greater specificity to pathology in Alzheimer's disease. We analyzed the microstructural changes in rTg4510 and wild type mice at 8.5 months. We correlated microstructural findings with histological measures of tau burden We compare two diffusion MR models: DTI and NODDI. Both models revealed changes in tissue microstructure due to tau pathology. The NODDI metrics demonstrated a good correlation with histological measures of tau burden.