Successful lung transplant cases with ex vivo lung perfusion assessment of extended criteria donor lungs

Successful lung transplant cases with ex vivo lung perfusion assessment of extended criteria donor lungs
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对扩展标准供肺进行离体肺灌注评估的成功肺移植病例

DOI:
10.1007/s11748-022-01774-x
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发表时间:
2022
影响因子:
1.2
通讯作者:
Hiroshi Date
Hiroshi Date
中科院分区:
医学4区
文献类型:
--
作者:
Daisuke Nakajima;Shunichi Nagata,Hidenao Kayawake;Satona Tanaka;Yoshito Yamada;Yojiro Yutaka;Akihiro Ohsumi;Masatsugu Hamaji;Toyofumi F. Chen-Yoshikawa;Hiroshi Date

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我们报告了我们在两例肺移植病例中的成功经验,其中体外肺灌注(EVLP)用于评估受伤的脑死亡供体肺的功能,否则最初是不可接受的。在供体肺被所有其他移植中心拒绝移植后,肺被提供给我院列出的肺移植患者。在3小时EVLP评估后,供体肺功能被认为可接受移植。第1例患者,32岁,男性,造血干细胞移植后并发闭塞性细支气管炎,行混合肺移植,即右侧脑死亡供体肺移植联合左侧保留自体上叶的活体肺叶移植。在第二个病例中,一名61岁的女性接受了右单肺移植治疗特发性肺纤维化。两名患者在肺移植后一年半的情况良好。
We report our successful experience in two lung transplant cases in which ex vivo lung perfusion (EVLP) was used to evaluate the function of injured brain-dead donor lungs that were otherwise initially unacceptable. After the donor’s lungs were declined for transplantation by all other transplant centers, the lungs were offered to the patients listed for lung transplantation in our hospital. The donor lung function was considered acceptable for transplantation after the 3-h EVLP assessment. In the first case, a 32-year-old man with bronchiolitis obliterans after hematopoietic stem cell transplantation underwent hybrid lung transplantation, that was right brain-dead donor lung transplantation, combined with native-upper lobe sparing living-donor lobar lung transplantation on the left side. In the second case, a 61-year-old woman received the right single lung transplantation for idiopathic pulmonary fibrosis. Both patients are doing well at one and a half years after lung transplantation.
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