Ocular toxicity associated with high-dose carmustine.
Ocular toxicity associated with high-dose carmustine.
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DOI：
10.1001/archopht.1982.01030040746007
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发表时间：
1982-11
影响因子：
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通讯作者：
B. Shingleton;Don C. Bienfang;Daniel M. Albert;W. D. Ensminger;William F. Chandler;Harry S. Greenberg-Harry-S.-Greenber
中科院分区：
文献类型：
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作者：
B. Shingleton;Don C. Bienfang;Daniel M. Albert;W. D. Ensminger;William F. Chandler;Harry S. Greenberg-Harry-S.-Greenber
卡莫司汀（一种亚硝基脲）的眼部副作用尚未明确。在接受高剂量静脉（IV）卡莫司汀（800 mg/sq m）联合自体骨髓挽救治疗的50例患者中，有2例出现迟发性双眼毒性证据。IV治疗后4周，眼毒性症状或体征变得明显。在两次治疗中，接受颈动脉内卡莫司汀给药的10例患者中有7例出现了输注侧同侧迟发性眼毒性的证据，累积剂量最低为450 mg/sq m。眼毒性在动脉内治疗后2至14周（平均6周）开始。在这些患者中，有三名患者的视力丧失在一周内进展到没有光感。两组的眼底镜表现包括动脉狭窄、神经纤维层梗死和视网膜内出血。血管造影显示节段性血管周围染色、广泛晚期毛细血管渗漏和视盘荧光增强。1例患者经光学和显微镜证实为睫状视网膜动脉闭塞和脉络膜纤维蛋白血栓。
The ocular side effects of carmustine (a nitrosurea) are not well established. Evidence of delayed bilateral ocular toxicity developed in two of 50 patients treated with high dose intravenous (IV) carmustine (800 mg/sq m) with autologous bone marrow rescue. Symptoms or signs of ocular toxicity became apparent four weeks following IV treatment. Evidence of delayed ocular toxicity ipsilateral to the side of the infusion developed in seven of ten patients treated with intra-arterial carotid doses of carmustine to a cumulative minimum of 450 mg/sq m in two treatments. The ocular toxicity began two to 14 weeks (mean, six weeks) following intra-arterial treatment. In three of these patients, the visual loss progressed over one week to no light perception. The funduscopic manifestations of both groups included arterial narrowing, nerve fiber-layer infarcts, and intraretinal hemorrhages. Fluorescein angiography demonstrated segmental perivascular staining, wide-spread late capillary leakage, and optic disc hyperfluorescence. One patient had light and microscopic confirmation of cilioretinal artery occlusion and choroidal fibrin thrombi.