The transmission/disequilibrium test and parental-genotype reconstruction: The reconstruction-combined transmission/disequilibrium test
The transmission/disequilibrium test and parental-genotype reconstruction: The reconstruction-combined transmission/disequilibrium test
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DOI：
10.1086/302285
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发表时间：
1999-03-01
影响因子：
9.8
通讯作者：
Knapp, M
中科院分区：
文献类型：
--
作者：
Knapp, M
斯皮尔曼和埃文斯最近提出了一种测试疾病连锁标记的方法，该方法结合了具有和不具有父母基因型别信息的家庭的数据。对于一些没有父母基因信息的家庭，从他们后代的基因类型中重建缺失的父母基因类型是可能的。然而，对这样一个重建的家庭的处理，就像父母的基因类型已经被分型一样，可能会带来偏见。在本研究中，提出了一种新的方法，该方法采用父母-基因重建，并纠正重建所产生的偏差。将该方法应用于实际数据集和模拟研究的结果表明，该方法可以提高检测连锁的能力。
Spielman and Ewens recently proposed a method for testing a marker for linkage with a disease, which combines data from families with and without information on parental genotypes. For some families without parental-genotype information, it may be possible to reconstruct missing parental genotypes from the genotypes of their offspring. The treatment of such a reconstructed family as if parental genotypes have been typed, however, can introduce bias. In the present study, a new method is presented that employs parental-genotype reconstruction and corrects for the biases resulting from reconstruction. The results of an application of this method to a real data set and of a simulation study suggest that this approach may increase the power to detect linkage.