Clinical and histopathologic parameters in survival of oral squamous cell carcinoma
Clinical and histopathologic parameters in survival of oral squamous cell carcinoma
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DOI：
10.1016/j.oooo.2011.11.001
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发表时间：
2012-04-01
影响因子：
2.9
通讯作者：
Tilakaratne, Wanninayake Mudiyanselage
中科院分区：
文献类型：
--
作者：
Dissanayaka, Waruna Lakmal;Pitiyage, Gayani;Tilakaratne, Wanninayake Mudiyanselage
Objective.本研究的目的是评估斯里兰卡口腔鳞状细胞癌（OSCC）患者生存的临床和组织病理学参数的相关性。对193例先前诊断为口腔鳞癌的患者进行了长达5年的随访。分析治疗后局部复发和5年生存率的临床和组织病理学参数。部位、分期、局部复发、分化程度、角化程度、浸润方式和切缘状态与5年生存率显著相关（P <0.05）。多因素分析表明，分期、浸润方式和切缘状态是口腔鳞癌真正独立的预后指标。在考克斯回归模型中，浸润方式是局部复发和总生存率的最佳预测因素（P < .001）。与其他参数相比，分期、浸润方式和切缘状态是OSCC的上级预后指标。(Oral外科口腔医学口腔病理学口腔放射学2012;113：518-525）
Objective. The aim of this study was to assess the relevance of clinical and histopathologic parameters on survival of oral squamous cell carcinoma (OSCC) patients in Sri Lanka.Study Design. A cohort of 193 previously diagnosed OSCC patients were followed for up to 5 years. Clinical and histopathologic parameters were analyzed regarding local recurrence and 5-year survival after treatment.Results. Site, stage, local recurrence, degree of differentiation, degree of keratinization, pattern of invasion, and status of the excision margins showed a significant association with the 5-year survival (P < .05). Multivariate analysis identified stage, pattern of invasion, and status of the excision margins as true independent prognostic indicators of OSCC. Pattern of invasion was the best prognosticator of both local recurrence and overall survival in the Cox regression model (P < .001).Conclusions. Stage, pattern of invasion, and status of the excision margins are superior prognostic indicators of OSCC compared with other parameters. (Oral Surg Oral Med Oral Pathol Oral Radiol 2012;113:518-525)