WISE-2005: Bed-rest induced changes in bone mineral density in women during 60 days simulated microgravity
WISE-2005: Bed-rest induced changes in bone mineral density in women during 60 days simulated microgravity
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DOI：
10.1016/j.bone.2011.06.021
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发表时间：
2011-10-01
期刊：
影响因子：
4.1
通讯作者：
Felsenberg, Dieter
中科院分区：
文献类型：
--
作者：
Beller, Gisela;Belavy, Daniel L.;Felsenberg, Dieter
为了更好地了解长期卧床对女性的影响，24名25至40岁的健康女性参加了60天的严格6度头低位卧床（WISE-2005）。受试者被分配到对照组（CON，n = 8），不采取任何对策，运动组（EXE，n = 8）进行阻力和耐力训练的组合或营养组（NUT，n = 8），其中接受高蛋白饮食。采用外周定量计算机断层扫描（pQCT）和双能X线吸收测定法（DXA），测量卧床休息后1年内各部位骨密度（BMD）、身体成分、小腿和前臂肌肉横截面积的变化。胫骨远端和股骨近端的骨丢失最大，尽管也观察到桡骨远端骨小梁密度的丢失。其中一些骨丢失在卧床休息一年后仍具有统计学显著性。与对照组相比，两种对策均未对骨丢失造成统计学显著阻碍。然而，运动对策确实减少了下肢的肌肉横截面积和瘦体重损失，也导致了更大的脂肪量损失，而营养对策对这些参数没有影响。研究结果表明，在长期卧床休息的妇女中，骨丢失的区域差异在卧床休息一年后不完全恢复。所实施的对策在预防卧床期间骨丢失方面并不理想，需要进一步开发。(C)2011 Elsevier Inc. All rights reserved.
To better understand the effects of prolonged bed-rest in women, 24 healthy women aged 25 to 40 years participated in 60-days of strict 6 degrees head-down tilt bed-rest (WISE-2005). Subjects were assigned to either a control group (CON, n = 8) which performed no countermeasure, an exercise group (EXE, n = 8) undertaking a combination of resistive and endurance training or a nutrition group (NUT, n = 8), which received a high protein diet. Using peripheral quantitative computed tomography (pQCT) and dual X-ray absorptiometry (DXA), bone mineral density (BMD) changes at various sites, body-composition and lower-leg and forearm muscle cross-sectional area were measured up to 1-year after bed-rest. Bone loss was greatest at the distal tibia and proximal femur, though losses in trabecular density at the distal radius were also seen. Some of these bone losses remained statistically significant one-year after bed-rest. There was no statistically significant impediment of bone loss by either countermeasure in comparison to the control-group. The exercise countermeasure did, however, reduce muscle cross-sectional area and lean mass loss in the lower-limb and also resulted in a greater loss of fat mass whereas the nutrition countermeasure had no impact on these parameters. The findings suggest that regional differences in bone loss occur in women during prolonged bed-rest with incomplete recovery of this loss one-year after bed-rest. The countermeasures as implemented were not optimal in preventing bone loss during bed-rest and further development is required. (C) 2011 Elsevier Inc. All rights reserved.