Effects of environmental enrichment in aged mice on anxiety-like behaviors and neuronal nitric oxide synthase expression in the brain
Effects of environmental enrichment in aged mice on anxiety-like behaviors and neuronal nitric oxide synthase expression in the brain
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DOI：
10.1016/j.bbrc.2016.06.010
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发表时间：
2016-08-05
影响因子：
3.1
通讯作者：
Higaki, Yasuki
中科院分区：
文献类型：
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作者：
Tomiga, Yuki;Ito, Ai;Higaki, Yasuki
以往的研究表明，丰富的环境（EE）通过神经元一氧化氮合酶/一氧化氮（nNOS/NO）通路对幼龄和老年动物的脑功能有重要影响。然而，EE是否通过改变nNOS表达水平诱导其作用以及是否降低老年小鼠的焦虑样行为尚不清楚。在这里，我们发现老年小鼠海马和小脑中nNOS的表达水平随着年龄的增长而增加，但在皮层中没有。此外，EE减少了老年小鼠的焦虑样行为，降低了小脑而非皮质的nNOS表达水平。本研究表明，情感表达通过改变海马或小脑中nNOS的表达水平来改善老年小鼠的焦虑样行为。(C) 2016 Elsevier Inc.版权所有。
Previous studies have shown that an enriched environment (EE) has an important effect on brain function via the neuronal nitric oxide synthase/nitric oxide (nNOS/NO) pathway in young and aged animals. However, whether EE induces its effect by altering nNOS expression levels and whether it lowers anxiety-like behaviors in aged mice remains unclear. Here, we show that nNOS expression levels increased with age in the hippocampus and cerebellum in aged mice, but not in the cortex. Moreover, EE reduced anxiety-like behaviors in aged mice and reduced nNOS expression levels in the cerebellum, but not in the cortex. The present study suggests that EE improves anxiety-like behaviors in aged mice by altering nNOS expression levels in the hippocampus or cerebellum. (C) 2016 Elsevier Inc. All rights reserved.