Human X Chromosome Carries Quantitative Genes for Immunoglobulin M
Human X Chromosome Carries Quantitative Genes for Immunoglobulin M
复制标题
人类 X 染色体携带免疫球蛋白 M 的定量基因
作者：
F. J. Grundbacher
在弗吉尼亚州的黑人和白色人群中，女性血清中免疫球蛋白M的浓度比男性高三分之一。在家庭研究中，男孩与其母亲之间的关系比男孩与其父亲之间的关系密切得多。女孩的免疫球蛋白M浓度与其父亲的相关性比与其母亲的相关性更密切。较高的平均值IgM在女性和父母和后代之间的相关系数的相对幅度支持的假设，即人的X染色体携带的基因与IgM浓度的影响。免疫球蛋白A或G未显示这些模式。
Concentrations of immunoglobulin M in serum were one-third higher in females than in males in the Black and White populations of Virginia. In family studies, a much closer correlation was shown between boys and their mothers than between boys and their fathers. The immunoglobulin M concentrations in girls were more closely correlated with those of their fathers than with those of their mothers. The higher mean values for IgM in females and the relative magnitudes of the correlation coefficients between parents and offspring support the hypothesis that the X chromosome of man carries genes with an effect on IgM concentration. These patterns were not demonstrated for immunoglobulins A or G.