Systemic and uteroplacental renin--angiotensin system in normal and pre-eclamptic pregnancies.
Systemic and uteroplacental renin--angiotensin system in normal and pre-eclamptic pregnancies.
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DOI：
10.1177/1753944708094529
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发表时间：
2008-10
影响因子：
2.3
通讯作者：
Brosnihan KB
中科院分区：
文献类型：
--
作者：
Anton L;Brosnihan KB
怀孕的特点是循环肾素-血管紧张素系统 [RAS] 中许多不同成分的增加。然而，怀孕期间 RAS 活性受到刺激的生理机制尚不清楚。更不为人所知的是，在先兆子痫（一种妊娠期高血压疾病）中，这个系统是如何改变的。其他研究表明，正常和先兆子痫妊娠的子宫胎盘单位中存在局部组织特异性 RAS。正常妊娠和先兆子痫 RAS 成分调节的差异可能有助于深入了解先兆子痫临床病理特征的机制。具体而言，本综述总结了正常妊娠和先兆子痫妊娠中循环和子宫胎盘 RAS 的主要发现。
Pregnancy is characterized by an increase in many of the different components of the circulating renin–angiotensin system [RAS]. However, the physiological mechanisms of stimulated RAS activity during pregnancy are unknown. Even less understood is how this system may be altered in pre-eclampsia, a hypertensive disorder of pregnancy. Additional studies have shown the presence of a local tissue specific RAS in the uteroplacental unit of normal and pre-eclamptic pregnancies. Differences in normal pregnant and pre-eclamptic RAS component regulation may provide insight into the mechanisms responsible for the clinical pathological features of pre-eclampsia. Specifically, this review summarizes the key findings in the circulating and uteroplacental RAS in normal and pre-eclamptic pregnancies.