The value of MG7-Ag and COX-2 for predicting malignancy in gastric precancerous lesions
The value of MG7-Ag and COX-2 for predicting malignancy in gastric precancerous lesions
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MG7-Ag和COX-2对胃癌前病变恶性程度的预测价值
DOI：
10.1042/cbi20100149
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发表时间：
2010-09-01
影响因子：
3.9
通讯作者：
Fan, Daiming
中科院分区：
文献类型：
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作者：
Hong, Liu;Li, Shujun;Fan, Daiming
本研究旨在首次探讨MG 7-Ag和考克斯-2联合检测在胃癌前病变进展预测中的临床价值。采用免疫组织化学方法检测396例胃癌前病变组织中MG 7-Ag和考克斯-2的表达，其中萎缩性胃炎66例，肠上皮化生106例，低度中度异型增生174例，高度异型增生50例。随访分析MG 7-Ag和考克斯-2染色与各种临床病理特征的关系。MG 7-Ag和考克斯-2的阳性率从萎缩性胃炎（21.2%、28.8%）、肠上皮化生（36.8%、44.3%）、低中度异型增生（51.4%、58.6%）到高度异型增生（72%、80%）逐渐增高。胃癌前病变中MG 7-Ag和考克斯-2双阳性者发生胃癌前病变的危险性是阴性者的22倍以上。MG 7-Ag和考克斯-2的表达与患者的性别、年龄无关。MG 7-Ag和考克斯-2在胃癌的发生、发展过程中可能起重要作用。联合检测MG 7-Ag和考克斯-2对预测早期胃癌和癌前病变有一定价值。
Here we aimed to first investigate the clinical value of combined detection of MG7-Ag and COX-2 (cyclo-oxygenase 2) in prediction of advances in gastric precancerous lesions. Immunohistochemical analysis was used to examine the expression of MG7-Ag and COX-2 in 396 cases of patients with gastric precancerous lesions, including 66 cases of atrophic gastritis, 106 cases of intestinal metaplasia, 174 cases of low-moderate-grade dysplasia and 50 cases of high-grade dysplasia. The relation of MG7-Ag and COX-2 staining with various clinicopathological features was analysed by follow-up study. The positive rates of MG7-Ag and COX-2 were increased gradually from atrophic gastritis (21.2%, 28.8%), intestinal metaplasia (36.8%, 44.3%), low-moderate-grade dysplasia (51.4%, 58.6%) to high-grade dysplasia (72%, 80%). Double positive staining of MG7-Ag and COX-2 in gastric precancerous lesions had an increased risk of precancerous progression over 22 times, compared with negative ones. However, the expression of MG7-Ag and COX-2 was not significantly correlated with age and gender of patients. MG7-Ag and COX-2 might play an important role in the process of carcinogenesis and progression of gastric cancer. Combined detection of MG7-Ag and COX-2 was of value of predicting early gastric cancer from precancerous lesions.