The adhesion GPCR latrophilin/CIRL shapes mechanosensation.
The adhesion GPCR latrophilin/CIRL shapes mechanosensation.
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DOI：
10.1016/j.celrep.2015.04.008
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发表时间：
2015-05
期刊：
影响因子：
8.8
通讯作者：
Nicole Scholz;J. Gehring;Chonglin Guan;Dmitrij Ljaschenko;Robin Fischer;Vetrivel Lakshmanan;R. Kittel;T. Langenhan
中科院分区：
文献类型：
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作者：
Nicole Scholz;J. Gehring;Chonglin Guan;Dmitrij Ljaschenko;Robin Fischer;Vetrivel Lakshmanan;R. Kittel;T. Langenhan
G蛋白偶联受体（GPCR）通常被认为是响应可溶性细胞外信号而控制细胞状态的化学传感器。然而，通过粘附 GPCR (aGPCR)（GPCR 超家族的第二大类）识别的刺激方式尚未解决。我们的研究表征了果蝇aGPCRLatrophilin/dCirl，它是这一神秘受体类别的原型成员。我们表明，dCirl 通过脊索神经元（果蝇的主要机械传感器）塑造触觉、本体感觉和听觉刺激的感知。dCirl 通过放大这些神经元的输入输出功能来使这些神经元敏感，以检测机械刺激。我们的结果表明，aGPCR 通常可以处理和调节机械信号的感知，将这些重要的刺激与 GPCR 超家族的感觉规范联系起来。
G-protein-coupled receptors (GPCRs) are typically regarded as chemosensors that control cellular states in response to soluble extracellular cues. However, the modality of stimuli recognized through adhesion GPCR (aGPCR), the second largest class of the GPCR superfamily, is unresolved. Our study characterizes theDrosophilaaGPCRLatrophilin/dCirl, a prototype member of this enigmatic receptor class. We show thatdCirlshapes the perception of tactile, proprioceptive, and auditory stimuli through chordotonal neurons, the principal mechanosensors ofDrosophila.dCirlsensitizes these neurons for the detection of mechanical stimulation by amplifying their input-output function. Our results indicate that aGPCR may generally process and modulate the perception of mechanical signals, linking these important stimuli to the sensory canon of the GPCR superfamily.