Pulmonary Embolism, Myocardial Infarction, and Ischemic Stroke in Lung Cancer Patients: Results from a Longitudinal Study
Pulmonary Embolism, Myocardial Infarction, and Ischemic Stroke in Lung Cancer Patients: Results from a Longitudinal Study
复制标题
肺癌患者的肺栓塞、心肌梗塞和缺血性中风：纵向研究结果
作者：
M. P. Herk;S. Shantakumar;F. P. Penning;P. Kamphuisen;C. Majoor;L. Overbeek;R. Herings
目的在这项队列研究中，比较肺癌（LC）诊断前后肺栓塞（PE）、心肌梗死（MI）和缺血性卒中（IS）的发生率与无癌对照组的发生率。方法2000-2007年期间LC患者选自荷兰病理学登记处PALGA，并与PHARMO医疗记录链接系统链接，包括荷兰300万居民的吸毒和住院情况。纳入的LC患者按年龄和性别与无癌症对照组1：10匹配。在12个月前和LC diagnosis.ResultsLC患者（N = 3，717）的PE，MI和IS住院治疗进行了评估，比无癌对照组有6倍的可能性有一个PE在12个月前诊断。LC诊断后，患者在前6个月内发生PE的风险极高（与对照组相比，风险比[HR] 16.8; 95%置信区间[CI] 7.6-36.8），此后风险降低至5倍增加（HR 5.1; 95% CI 2.7-9.4）。然而，在这两个时间段内，每100人年发生的事件不到两起。接受化疗的LC患者发生PE的可能性增加8倍，而手术增加PE的风险3倍。对于MI和IS，没有显着差异，观察与无癌对照之前或之后LC diagnosis.ConclusionsLC患者有较高的风险发展PE与无癌对照相比，虽然PE住院的频率低。手术和化疗与PE风险增加相关。
PurposeIn this cohort study, the rates of pulmonary embolism (PE), myocardial infarction (MI), and ischemic stroke (IS) before and after lung cancer (LC) diagnosis were compared to cancer-free controls.MethodsPatients with LC during 2000–2007 were selected from PALGA, the Dutch Pathology Registry, and linked to the PHARMO medical record linkage system, including drug use and hospitalizations of 3 million inhabitants in the Netherlands. Included LC patients were matched 1:10 by age and gender to cancer-free controls. Hospitalizations for PE, MI, and IS were assessed in the 12 months before and after LC diagnosis.ResultsLC patients (N = 3,717) were six times more likely than cancer-free controls to have had a PE in the 12 months before diagnosis. After LC diagnosis, patients experienced an extremely increased risk of PE in the first 6 months (hazard ratio [HR] 16.8; 95 % confidence interval [CI] 7.6–36.8) compared with controls), which decreased to a five times increased risk (HR 5.1; 95 % CI 2.7–9.4) thereafter. However, there were less than two events per 100 person years during both time periods. LC patients receiving chemotherapy were eight times more likely to develop PE, whereas surgery increased the risk on PE three times. For MI and IS, no significant difference was observed compared with cancer-free controls before or after LC diagnosis.ConclusionsLC patients have a higher risk of developing PE compared with cancer-free controls, although the frequency of PE hospitalizations was low. Surgery and chemotherapy were associated with an increased risk of PE.
影响因子：
3
作者：
Wolinsky,FD;Wan,GJ;Gurney,JG;Bentley,DW
通讯作者：
Bentley,DW
影响因子：
--
作者：
W. Kniffin;J. Baron;J. Barrett;J. Birkmeyer;F. Anderson
通讯作者：
W. Kniffin;J. Baron;J. Barrett;J. Birkmeyer;F. Anderson
影响因子：
45.3
作者：
Khorana, AA;Francis, CW;Lyman, GH
通讯作者：
Lyman, GH