Takanawaenes, novel antifungal antibiotics produced by Streptomyces sp. K99-5278. I. Taxonomy, fermentation, isolation and biological properties.
Takanawaenes, novel antifungal antibiotics produced by Streptomyces sp. K99-5278. I. Taxonomy, fermentation, isolation and biological properties.
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Takanawaenes，由链霉菌产生的新型抗真菌抗生素。
DOI：
10.7164/antibiotics.56.448
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
S. Ōmura
中科院分区：
文献类型：
--
作者：
Yong;H. Tomoda;K. Iizima;T. Fukuda;A. Matsumoto;Yōko Takahashi;S. Ōmura
从链霉菌发酵液中分离得到3个新的28元环五烯大环内酯类化合物，命名为竹节内酯A、B和C。K99-5278经溶剂萃取、硅胶柱层析和高效液相色谱分离。对黑曲霉、总状毛霉、白色念珠菌和酿酒酵母有一定的抑菌活性。
Three new pentaene macrolides having a 28-membered ring, designated takanawaenes A, B and C, were isolated from the fermentation broth of Streptomyces sp. K99-5278 by solvent extraction, silica-gel column chromatography and HPLC. Takanawaenes showed antifungal activity against Aspergillus niger, Mucor racemosus, Candida albicans and Saccharomyces cerevisiae.