Discoidin domain receptor functions in physiological and pathological conditions.
Discoidin domain receptor functions in physiological and pathological conditions.
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DOI：
10.1016/b978-0-12-800180-6.00002-5
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发表时间：
2014
影响因子：
--
通讯作者：
Leitinger, Birgit
中科院分区：
文献类型：
--
作者：
Leitinger, Birgit
盘状结构域受体DDR1和DDR2是非整合素胶原受体，是受体酪氨酸激酶家族的成员。这两种DDR都结合了许多不同类型的胶原，并在胚胎发育中发挥着重要作用。DDR功能失调与多种人类疾病的进展有关，包括纤维化、关节炎和癌症。通过与细胞外基质的关键成分相互作用并表现出不同的激活动力学，DDRs形成了一个独特的受体酪氨酸激酶亚家族。DDR促进的细胞功能包括细胞迁移、细胞存活、增殖和分化，以及细胞外基质的重塑。本文就DDR-配体相互作用、DDR启动的信号通路以及调节受体功能的分子机制等方面的研究现状进行综述。还讨论了DDRs在发育和疾病进展中的作用。
The discoidin domain receptors, DDR1 and DDR2, are non-integrin collagen receptors that are members of the receptor tyrosine kinase family. Both DDRs bind a number of different collagen types and play important roles in embryo development. Dysregulated DDR function is associated with progression of various human diseases, including fibrosis, arthritis and cancer. By interacting with key components of the extracellular matrix and displaying distinct activation kinetics, the DDRs form a unique subfamily of receptor tyrosine kinases. DDR-facilitated cellular functions include cell migration, cell survival, proliferation and differentiation, as well as remodelling of extracellular matrices. This review summarises the current knowledge of DDR-ligand interactions, DDR-initiated signal pathways and the molecular mechanisms that regulate receptor function. Also discussed are the roles of DDRs in development and disease progression.