Coronary heart disease and stroke attributable to major risk factors is similar in Argentina and the United States: the Coronary Heart Disease Policy Model.
Coronary heart disease and stroke attributable to major risk factors is similar in Argentina and the United States: the Coronary Heart Disease Policy Model.
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DOI：
10.1016/j.ijcard.2011.04.013
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发表时间：
2011-08-04
影响因子：
3.5
通讯作者：
Goldman, Lee
中科院分区：
文献类型：
--
作者：
Moran, Andrew;DeGennaro, Vincent;Ferrante, Daniel;Coxson, Pamela G.;Palmas, Walter;Mejia, Raul;Perez-Stable, Eliseo J.;Goldman, Lee
心血管疾病是阿根廷和美国的主要死亡原因。阿根廷92%的城市人口，心血管疾病风险因素水平接近美国。冠心病（CHD）政策模型是一个全国范围的CHD和中风计算机模型。风险因素数据来自拉丁美洲心血管风险因素多重评价研究（2003-04）、阿根廷国家风险因素调查（2005）和美国国家调查。通过将风险因素设定为最佳暴露水平[收缩压（SBP）115 mm Hg、低密度脂蛋白胆固醇（LDL）2.00 mmol/l（78 mg/dl）、高密度脂蛋白胆固醇（HDL）1.03 mmol/l（60 mg/dl）、无糖尿病和吸烟]，模拟2005-2015年期间归因于风险因素的心血管事件比例。假定归因于体重指数（BMI）> 21 kg/m2的心血管疾病通过SBP、LDL、HDL和糖尿病介导。阿根廷和美国的心血管疾病主要危险因素相似，除了男性SBP升高（阿根廷男性CHD高8%，中风高6%）。在美国，归因于BMI > 21 kg/m2的CHD显著更高（男性高10- 11%;女性CHD高13-14%）。在阿根廷和美国，由主要危险因素引起的心血管疾病的预测似乎相似，尽管BMI升高可能是美国心血管疾病的主要原因。一个高度城市化的中等收入国家的心血管疾病发病率和危险因素水平可能与高收入国家相当，但用于防治这一流行病的资源较少。
Cardiovascular disease is the leading cause of death in Argentina and the U.S. Argentina is 92% urban, with cardiovascular disease risk factor levels approximating the U.S. The Coronary Heart Disease (CHD) Policy Model is a national-scale computer model of CHD and stroke. Risk factor data were obtained from the Cardiovascular Risk Factor Multiple Evaluation in Latin America Study (2003–04), Argentina National Risk Factor Survey (2005) and U.S. national surveys. Proportions of cardiovascular events over 2005–2015 attributable to risk factors were simulated by setting risk factors to optimal exposure levels [systolic blood pressure (SBP) 115 mm Hg, low-density lipoprotein cholesterol (LDL) 2.00 mmol/l (78 mg/dl), high-density lipoprotein cholesterol (HDL) 1.03 mmol/l (60 mg/dl), absence of diabetes, and smoking]. Cardiovascular disease attributable to body mass index (BMI) > 21 kg/m2 was assumed mediated through SBP, LDL, HDL, and diabetes. Cardiovascular disease attributable to major risk factors was similar between Argentina and the U.S., except for elevated SBP in men (CHD 8 % points higher in Argentine men, 6% higher for stroke). CHD attributable to BMI > 21 kg/m2 was substantially higher in the U.S. (men 10–11 % points higher; women CHD 13–14% higher). Projected cardiovascular disease attributable to major risk factors appeared similar in Argentina and the U.S., though elevated BMI may be responsible for more of U.S. cardiovascular disease. A highly urbanized middle-income nation can have cardiovascular disease rates and risk factor levels comparable to a high income nation, but fewer resources for fighting the epidemic.
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DOI：
10.1056/nejmoa0907355
发表时间：
2010-02-18
期刊：
The New England journal of medicine
影响因子：
--
作者：
Bibbins-Domingo K;Chertow GM;Coxson PG;Moran A;Lightwood JM;Pletcher MJ;Goldman L
通讯作者：
Goldman L
影响因子：
168.9
作者：
Lewington, S;Clarke, R;Collins, R
通讯作者：
Collins, R
影响因子：
168.9
作者：
Lavados, PM;Sacks, C;Alvarez, G
通讯作者：
Alvarez, G
影响因子：
168.9
作者：
Ezzati, M;Vander Hoorn, S;Murray, CJL
通讯作者：
Murray, CJL
影响因子：
120.7
作者：
Gu, DF;He, J;Whelton, PK
通讯作者：
Whelton, PK