Ultrastable Near-Infrared Conjugated-Polymer Nanoparticles for Dually Photoactive Tumor Inhibition
Ultrastable Near-Infrared Conjugated-Polymer Nanoparticles for Dually Photoactive Tumor Inhibition
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用于双重光活性肿瘤抑制的超稳定近红外共轭聚合物纳米粒子
DOI：
10.1002/adma.201700487
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发表时间：
2017
影响因子：
29.4
通讯作者：
Chen Huabing
中科院分区：
文献类型：
--
作者：
Yang Tao;Liu Ling;Deng Yibin;Guo Zhengqing;Zhang Guobing;Ge Zhishen;Ke Hengte;Chen Huabing
人们迫切希望开发出具有理想生物物理特性的光活性剂用于有效的癌症光治疗。本文中，开发了低带隙供体-受体（D-A）型共轭聚合物纳米颗粒（CP-NP）的双功能纳米颗粒，以提供用于近红外（NIR）光诱导的光动力（PDT）/光热（PTT）处理的高效的单线态到三线态跃迁和光热转换。CP-NP显示出显著的NIR吸收，峰值在782 nm处，并且对光漂白具有完美的抗性。光激发的CP-NP通过激发的D-A系统中的电荷转移进行单重态到三重态的系统间交叉，并且在单波长NIR光照射下从缺电子电子受体异靛衍生物同时进行非辐射衰变，从而导致独特的单重态氧量子产率和高光热转换效率。此外，CP-NP显示有效的细胞摄取和来自溶酶体的细胞质易位，以及有效的肿瘤蓄积，从而促进由有利的活性氧（ROS）产生和有效的高热引起的严重光触发损伤。因此，CP-NP通过其光转化能力实现光活性细胞损伤，用于协同PDT/PTT治疗与肿瘤消融。具有理想生物物理特性的D-A-型共轭聚合物纳米颗粒的概念验证设计提供了一种提供有效光敏癌症治疗的通用方法。
It is highly desired that satisfactory photoactive agents with ideal photophysical characteristics are explored for potent cancer phototherapeutics. Herein, bifunctional nanoparticles of low‐bandgap donor–acceptor (D–A)‐type conjugated‐polymer nanoparticles (CP‐NPs) are developed to afford a highly efficient singlet‐to‐triplet transition and photothermal conversion for near‐infrared (NIR) light‐induced photodynamic (PDT)/photothermal (PTT) treatment. CP‐NPs display remarkable NIR absorption with the peak at 782 nm, and perfect resistance to photobleaching. Photoexcited CP‐NPs undergo singlet‐to‐triplet intersystem crossing through charge transfer in the excited D–A system and simultaneous nonradiative decay from the electron‐deficient electron acceptor isoindigo derivative under single‐wavelength NIR light irradiation, leading to distinct singlet oxygen quantum yield and high photothermal conversion efficiency. Moreover, the CP‐NPs display effective cellular uptake and cytoplasmic translocation from lysosomes, as well as effective tumor accumulation, thus promoting severe light‐triggered damage caused by favorable reactive oxygen species (ROS) generation and potent hyperthermia. Thus, CP‐NPs achieve photoactive cell damage through their photoconversion ability for synergistic PDT/PTT treatment with tumor ablation. The proof‐of‐concept design of D–A‐type conjugated‐polymer nanoparticles with ideal photophysical characteristics provides a general approach to afford potent photoactive cancer therapy.