The management of drug-induced gingival overgrowth
The management of drug-induced gingival overgrowth
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DOI：
10.1111/j.1600-051x.2006.00930.x
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发表时间：
2006-06-01
影响因子：
6.7
通讯作者：
Seymour, RA
中科院分区：
文献类型：
--
作者：
Mavrogiannis, M;Ellis, JS;Seymour, RA
目的：本综述对药物诱导的过度生长(DIGO)的不同治疗方法进行了评价。材料和方法：本综述基于在线数据库MEDLINE和PUB MED的文献。这不是一个系统的回顾，而是对相关文献的常规回顾。结果：如果非手术方法可以在开始用药前提供，患者将受益，尽管在许多情况下这可能是不可行的。系统性抗生素的使用已经在环孢素引起的牙龈过度生长的管理中进行了评估。疗效似乎不明确，长期使用是不可取的。手术切除仍然是主要的治疗选择，特别是对于严重生长过度的患者。很少有研究比较不同术式的复发率或术后后遗症。结论：Digo是一个常见的临床问题，经常需要干预。非手术技术可以限制这种不想要的影响的发生，减少菌斑引起的牙周炎的程度，并降低复发率。只要有可能，应首先采用这一管理策略。手术治疗通常是最可靠的选择，而手术刀牙龈切除术仍然是治疗的首选。需要进一步调查，以制定适当的管理战略，以防止DIGO的再次发生。
Objectives: This review critically evaluates the different therapies that are available to manage drug-induced overgrowth (DIGO).Material and Methods: This review is based on literature identified using the online databases MEDLINE and PUB MED. It is not a systematic review, but a conventional review of the relevant literature.Results: Patients benefit from a non-surgical approach if this can be delivered before commencement of medication although in many instances this may not be practicable. Systemic antibiotic usage has been evaluated in the management of ciclosporin-induced gingival overgrowth. Efficacy appears to be equivocal and long-term use is undesirable. Surgical excision remains the main treatment option especially for patients with severe overgrowth. Few studies have compared different techniques with respect to recurrence rate or post-operative sequelae.Conclusion: DIGO is a common clinical problem that often requires intervention. Non-surgical techniques can limit the occurrence of this unwanted affect, reduce the extent of plaque-induced gingival inflammation and reduce the rate of recurrence. Wherever possible this management strategy should be adopted first. Surgical treatment is often the most reliable option and scalpel gingivectomy remains the treatment of choice. Further investigations are required to develop appropriate management strategies to prevent recurrence of DIGO.