Infection and transmission of SARS-CoV-2 in London care homes reporting no cases or outbreaks of COVID-19: Prospective observational cohort study, England 2020.
Infection and transmission of SARS-CoV-2 in London care homes reporting no cases or outbreaks of COVID-19: Prospective observational cohort study, England 2020.
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DOI：
10.1016/j.lanepe.2021.100038
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Zambon M
中科院分区：
文献类型：
--
作者：
Jeffery-Smith A;Dun-Campbell K;Janarthanan R;Fok J;Crawley-Boevey E;Vusirikala A;Fernandez Ruiz De Olano E;Sanchez Perez M;Tang S;Rowland TA;Wynne-Evans E;Bell A;Patel B;Amin-Chowdhury Z;Aiano F;Paranthaman K;Ma T;Saavedra-Campos M;Ellis J;Lackenby A;Whitaker H;Myers R;Höschler K;Brown K;Ramsay ME;Shetty N;Chow JY;Ladhani S;Zambon M
护理院受到COVID-19大流行的不成比例的影响。我们调查了伦敦养老院中无症状感染和无声传播的潜在作用，这些养老院在第一波大流行期间没有报告COVID-19病例。五周后，对五家无病例的护理院和两家报告了一例COVID-19病例的护理院（非爆发家庭）进行了鼻拭子SARS-CoV-2 RT-PCR和SARS-CoV-2抗体血清学调查。对RT-PCR阳性样本进行全基因组测序（WGS）。血清学结果进行了比较，与六个护理院与公认的爆发。在7个非疫情家庭中，718人（387名工作人员，331名居民）进行了鼻拭子检查，651人（386名工作人员，265名居民）进行了后续血清学检查。在五个护理院没有报告的情况下，16个人（13名居民，3名工作人员）RT-PCR阳性（护理院阳性率，0至7.6%）相比，13个人（3.0和10.8%阳性）在两个家庭报告一个单一的情况。这七个家庭的血清阳性率在10.7- 56.5%之间变化，其中四个超过了伦敦的社区血清阳性率（14.8%）。在13个家庭中，工作人员和居民的血清阳性率显著相关（rs 0.84，[95% CI 0.51-0.95] p <0.001）。WGS确定了多个介绍到一些家庭和一个家庭的工作人员和居民之间的一个单一的血统无声传输。我们发现，即使在没有COVID-19病例的养老院，无症状感染和传播的比率也很高。与RT-PCR阳性相比，较高的血清阳性率突出了沉默爆发的真实程度。PHE
Care homes have been disproportionately affected by the COVID-19 pandemic. We investigated the potential role of asymptomatic infection and silent transmission in London care homes that reported no cases of COVID-19 during the first wave of the pandemic. Five care homes with no cases and two care homes reporting a single case of COVID-19 (non-outbreak homes) were investigated with nasal swabbing for SARS-CoV-2 RT-PCR and serology for SARS-CoV-2 antibodies five weeks later. Whole genome sequencing (WGS) was performed on RT-PCR positive samples. Serology results were compared with those of six care homes with recognised outbreaks. Across seven non-outbreak homes, 718 (387 staff, 331 residents) individuals had a nasal swab and 651 (386 staff, 265 residents) had follow-up serology. Sixteen individuals (13 residents, 3 staff) in five care homes with no reported cases were RT-PCR positive (care home positivity rates, 0 to 7.6%) compared to 13 individuals (3.0 and 10.8% positivity) in two homes reporting a single case. Seropositivity across these seven homes varied between 10.7-56.5%, with four exceeding community seroprevalence in London (14.8%). Seropositivity rates for staff and residents correlated significantly (rs 0.84, [95% CI 0.51-0.95] p <0.001) across the 13 homes. WGS identified multiple introductions into some homes and silent transmission of a single lineage between staff and residents in one home. We found high rates of asymptomatic infection and transmission even in care homes with no COVID-19 cases. The higher seropositivity rates compared to RT-PCR positivity highlights the true extent of the silent outbreak. PHE
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DOI：
10.1016/s2666-7568(20)30012-x
发表时间：
2020-10
期刊：
The lancet. Healthy longevity
影响因子：
--
作者：
Burton JK;Bayne G;Evans C;Garbe F;Gorman D;Honhold N;McCormick D;Othieno R;Stevenson JE;Swietlik S;Templeton KE;Tranter M;Willocks L;Guthrie B
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Guthrie B
影响因子：
158.5
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McMichael, Temet M.;Currie, Dustin W.;Duchin, Jeffrey S.
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Duchin, Jeffrey S.
影响因子：
11.8
作者：
Patel, Mahesh C.;Chaisson, Lelia H.;Ezike, Ngozi O.
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Ezike, Ngozi O.
影响因子：
13.8
作者：
Belmin, Joel;Um-Din, Nathavy;Lafuente-Lafuente, Carmelo
通讯作者：
Lafuente-Lafuente, Carmelo
影响因子：
15.1
作者：
Ladhani, Shamez N.;Chow, J. Yimmy;Zambon, Maria
通讯作者：
Zambon, Maria